Rojas-Carabali William, Chan Kevin, Cifuentes-Gonzalez Carlos, Agarwal Manisha, Sen Alok, Biswas Jyotirmay, Kharel Sitaula Ranju, La Distia Nora Rina, Utami Anna, Khatri Anadi, Mahendradas Padmamalini, Schlaen Ariel, Mishra Chitaranjan, Guex-Crosier Yan, Tsui Edmund, Ayachit Apoorva, Gangaputra Sapna, Kempen John H, Gupta Vishali, de-la-Torre Alejandra, Lee Bernett, Agrawal Rupesh
Tan Tock Seng Hospital, National Healthcare Group, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Programme for Ocular Inflammation & Infection Translational Research, National Healthcare Group, Singapore; Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Asia Pac J Ophthalmol (Phila). 2025 May-Jun;14(3):100199. doi: 10.1016/j.apjo.2025.100199. Epub 2025 Apr 25.
The Programme for Ocular Inflammation & Infection Translational Research (PROTON) registry collects real-world data on infectious and non-infectious ocular inflammatory diseases (OID) to enhance understanding of disease progression and treatment outcomes. This report presents the baseline characteristics of patients enrolled in two international multicentric studies, OASIS 1 and OASIS 2, over the first two years.
A cross-sectional observational study.
PROTON is an observational ambispective cohort registry comprising OASIS 1, a retrospective study (2000-2021), and OASIS 2, a prospective study (2021 onwards). Data is collected at multiple intervals over a 10-year period, focusing on various OID. Participants include patients diagnosed with anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis, scleritis, retinal vasculitis, and neuroretinitis. Baseline characteristics, ocular examinations, and treatment outcomes are recorded.
A total of 2640 patients (3642 eyes) have been recruited across 17 centers worldwide. Infectious was the most common etiology (31.6 %), followed by idiopathic (28.1 %), undetermined (21.7 %), and non-infectious (16.0 %). Most patients (54.8 %) were male, with anterior uveitis being the most common anatomical location (37.5 %). Visual impairment was present in 53.2 % of cases, with 18.8 % experiencing moderate (0.5-1.0 LogMAR) and 22.6 % severe impairment (>1.0 LogMAR). Tuberculosis (64.0 %) and toxoplasmosis (13.5 %) were the leading infectious causes, while HLA-B27-associated uveitis accounted for 19.4 % of non-infectious cases.
The PROTON registry provides valuable insights into the global spectrum of OID, with a substantial representation of infectious causes. This real-world evidence highlights the key prevalence of visual impairment and underscores the importance of research on this topic. As the registry evolves, it will help refine clinical management strategies and improve patient outcomes globally.
眼部炎症与感染转化研究项目（PROTON）登记处收集关于感染性和非感染性眼部炎症性疾病（OID）的真实世界数据，以增进对疾病进展和治疗结果的了解。本报告展示了在前两年参与两项国际多中心研究（OASIS 1和OASIS 2）的患者的基线特征。
一项横断面观察性研究。
PROTON是一个观察性双向队列登记处，包括OASIS 1（一项回顾性研究，2000 - 2021年）和OASIS 2（一项前瞻性研究，2021年起）。在10年期间的多个时间点收集数据，重点关注各种OID。参与者包括被诊断患有前葡萄膜炎、中间葡萄膜炎、后葡萄膜炎、全葡萄膜炎、巩膜炎、视网膜血管炎和视神经视网膜炎的患者。记录基线特征、眼部检查和治疗结果。
全球17个中心共招募了2640名患者（3642只眼）。感染是最常见的病因（31.6%），其次是特发性（28.1%）、未确定（21.7%）和非感染性（16.0%）。大多数患者（54.8%）为男性，前葡萄膜炎是最常见的解剖部位（37.5%）。53.2%的病例存在视力损害，其中18.8%为中度（0.5 - 1.0 LogMAR）损害，22.6%为重度损害（>1.0 LogMAR）。结核病（64.0%）和弓形虫病（13.5%）是主要的感染原因，而HLA - B27相关葡萄膜炎占非感染性病例的19.4%。
PROTON登记处为OID的全球范围提供了有价值的见解，感染原因占相当比例。这一真实世界证据突出了视力损害的关键患病率，并强调了对此主题进行研究的重要性。随着登记处的发展，它将有助于完善全球临床管理策略并改善患者预后。
