Wilson Naomi, Gajwani Ruchika, Fleming Michael, Findlay Mia, Stocks Helen, Walker Graham, Corcoran Neave, Minnis Helen
University of Glasgow, Glasgow, UK
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
BMJ Open. 2025 Apr 27;15(4):e090823. doi: 10.1136/bmjopen-2024-090823.
There is now emerging evidence to suggest a longitudinal association between specific neurodevelopmental conditions (NDCs) in childhood or adolescence (ie, autism, attention deficit hyperactivity disorder (ADHD) and tic disorders) and certain physical long-term conditions (LTCs) in adulthood. However, to date, this literature has never been comprehensively collated and appraised. As a result, our understanding of all the future health risks that young people with NDCs may collectively be at risk of is limited, and the factors which drive these adult health outcomes also remain obscure.
A search strategy has been developed in collaboration with two medical librarians and will be used to conduct systematic searches of MEDLINE, EMBASE, APA PsycINFO, CINAHL and Web of Science. Prospective longitudinal studies exploring the association between three common NDCs in childhood or adolescence (ie, ADHD, autism and tic disorders <18 years of age) and any physical LTC in adulthood (ie, >18 years of age) will be selected through title and abstract review, followed by a full-text review. Data extracted will include the definition of exposure and outcome, mediators or moderators investigated, confounders adjusted for, and crude and adjusted effect estimates. Risk of bias assessment will be conducted. Results will be synthesised narratively and, if the data allow, a meta-analysis will also be conducted.
Ethics approval is not applicable for this study since no original data will be collected. The results of the review will be widely disseminated locally, nationally and internationally through peer-reviewed publications, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, and conference presentations.
CRD42024516684.
现在有新出现的证据表明，儿童期或青少年期的特定神经发育状况（NDCs）（即自闭症、注意力缺陷多动障碍（ADHD）和抽动障碍）与成年期的某些身体长期疾病（LTCs）之间存在纵向关联。然而，迄今为止，该文献从未得到全面整理和评估。因此，我们对患有NDCs的年轻人可能共同面临的所有未来健康风险的了解有限，而且导致这些成年期健康结果的因素也仍不清楚。
已与两名医学图书馆员合作制定了检索策略，并将用于对MEDLINE、EMBASE、APA PsycINFO、CINAHL和科学网进行系统检索。将通过标题和摘要审查，然后进行全文审查，选择探索儿童期或青少年期三种常见NDCs（即ADHD、自闭症和18岁以下的抽动障碍）与成年期任何身体LTC（即18岁以上）之间关联的前瞻性纵向研究。提取的数据将包括暴露和结果的定义、所研究的中介或调节因素、调整的混杂因素以及粗略和调整后的效应估计值。将进行偏倚风险评估。结果将进行叙述性综合，如果数据允许，还将进行荟萃分析。
由于不收集原始数据，本研究无需伦理批准。审查结果将通过同行评审出版物、遵循系统评价和荟萃分析的首选报告项目声明以及会议报告在当地、国家和国际上广泛传播。
PROSPERO注册号：CRD42024516684。
