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重复经颅磁刺激联合双相抑郁三联疗法减少女性青少年非自杀性自伤的疗效评估

[Efficacy evaluation of repeated transcranial magnetic stimulation combined with bipolar depression triple therapy in reducing female adolescents' non-suicidal self-injury].

作者信息

Shen Yun, Li Jing, Zou Ke, Yang Kuanwei, Shu Yanping, Zheng Zhong

机构信息

Center of Neurobioassay, West China Hospital of Sichuan University, Chengdu 610041, P. R. China.

Women's Mental Health Branch, Second People's Hospital of Guizhou Province, Guiyang 550004, P. R. China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Apr 25;42(2):288-292. doi: 10.7507/1001-5515.202411008.

Abstract

In order to explore effective ways to reduce non-suicidal self-injury (NSSI) among female adolescents, a total of 45 female adolescent patients with NSSI in West China Hospital of Sichuan University and Guizhou Second Provincial People's Hospital from June 2021 to June 2024 were selected randomly that divided into groups A, B and C, with 15 cases in each group. Group A was treated with repeated transcranial magnetic stimulation (rTMS) and bipolar depression triple therapy, and group B was treated with bipolar depression triple therapy to compare the effectiveness and safety. Group C received bipolar depression triple therapy combined with sham stimulation which only produced stimulating sounds but no stimulating magnetic field as a control in the study. After treatment, the Hamilton Anxiety Score (HAMA), Hamilton Depression Score (HAMD) and Nurses' Global Assessment of Suicide Risk (NGASR) in group A were significantly lower than those in group B and C ( < 0.01). rTMS combined with bipolar depression triple therapy has a definite effect on reducing NSSI in female adolescents, which can reduce the incidence rate of short-term NSSI behavior in patients.

摘要

为探索降低女性青少年非自杀性自伤(NSSI)的有效方法,2021年6月至2024年6月,从四川大学华西医院和贵州省第二人民医院随机选取45例患有NSSI的女性青少年患者,分为A、B、C组,每组15例。A组采用重复经颅磁刺激(rTMS)联合双相抑郁三联疗法治疗,B组采用双相抑郁三联疗法治疗,比较两者的有效性和安全性。C组接受双相抑郁三联疗法联合假刺激治疗,假刺激仅产生刺激声音但无刺激磁场,作为本研究的对照。治疗后,A组的汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分及护士自杀风险整体评估(NGASR)均显著低于B组和C组(<0.01)。rTMS联合双相抑郁三联疗法对降低女性青少年NSSI有确切疗效,可降低患者短期NSSI行为发生率。

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