Zhou Shengshuo, Zhou Huajian, Du Xiaoyu, Yu Ziye, Xu Tongle, Zhao Shun, Su Peiqiang, Zhang Leian, Fu Guangyang, Liu Xuelei
School of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
Shandong Huiyu Auto Parts Co., Ltd., Binzhou, Shandong 251702, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Apr 25;42(2):423-430. doi: 10.7507/1001-5515.202408024.
Drug administration via hollow microneedles (HMN) have the advantages of painlessness, avoidance of first-pass effect, capability of sustained infusion, and no need for professional personnel operation. In addition, HMN can also be applied in the fields of body fluid extraction and biosensors, showing broad application prospects. However, traditional manufacturing technologies cannot meet the demand for low-cost mass production of HMN, limiting its widespread application. This paper reviews the main manufacturing technologies used for HMN in recent years, which include photolithography and etching, laser etching, sputtering and electroplating, micro-molding, three-dimensional (3D) printing and drawing lithography. It further analyzes the characteristics and limitations of existing manufacturing technologies and points out that the combination of various manufacturing technologies can improve production efficiency to a certain extent. In addition, this paper looks forward to the future trends of HMN manufacturing technology and proposes possible directions for its development. In conclusion, it is expected that this review can provide new ideas and references for follow-up research.
通过中空微针（HMN）给药具有无痛、避免首过效应、能够持续输注以及无需专业人员操作等优点。此外，HMN还可应用于体液提取和生物传感器领域，展现出广阔的应用前景。然而，传统制造技术无法满足HMN低成本大规模生产的需求，限制了其广泛应用。本文综述了近年来用于HMN的主要制造技术，包括光刻与蚀刻、激光蚀刻、溅射与电镀、微成型、三维（3D）打印和拉伸光刻。进一步分析了现有制造技术的特点和局限性，并指出多种制造技术的结合在一定程度上可以提高生产效率。此外，本文展望了HMN制造技术的未来趋势，并提出了其可能的发展方向。总之，期望本综述能为后续研究提供新思路和参考。
