Relationship of cranial bone signal intensity to multiple sclerosis clinical course and progression.

ObjectivesMultiple sclerosis (MS) usually relapses, about half become progressive after a period of time, few are progressive from the onset. Leptomeningeal ectopic lymphoid follicles with cell flow from the cranial bone marrow may be associated with progression. The aim of this retrospective study was to determine the predictive value of cranial bone signal intensity and to correlate it with other clinical features.MethodsRetrospective clinical and radiological characteristics of 96 MS patients (16 primary progressive multiple sclerosis, 80 relapsing-remitting multiple sclerosis (RRMS)) and 60 controls (tension-type headache) were recorded. Frontal (F), occipital (O), clivus (C) and vitreous body (V) signal intensities were measured. The relationship between clinical features, disease course and radiological findings were analyzed.ResultsThe mean age was 39.58±0.84 years. Twenty-five patients converted to secondary progressive multiple sclerosis (SPMS). Changes in the ratio of F, O, C density to V were similar between groups. At baseline, ratio of frontal bone marrow intensity to vitreous body intensity (F/V) was lower in SPMS and RRMS compared to control, and ratio of occipital bone marrow intensity to vitreous body intensity (O/V) was lower in SPMS compared to control. Low F/V on initial magnetic resonance imaging had diagnostic potential for RRMS, and low F/V and low O/V had diagnostic marker potential for conversion to SPMS.ConclusionsCranial bone intensity in multiple sclerosis patients may be a clue for future disease severity or conversion to SPMS.