Li Hongzhe, Tong Wentao, Hu Man, Meng Ziqi, Chang Pingjun, Zhao Yune
School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Curr Eye Res. 2025 Aug;50(8):785-790. doi: 10.1080/02713683.2025.2497324. Epub 2025 Apr 28.
To evaluate the changes in meibomian gland function, ocular surface parameters, and optical quality before and after meibomian gland expression in patients with meibomian gland dysfunction (MGD).
Patients with MGD underwent meibomian gland expression once weekly for 4 consecutive weeks. Comprehensive assessments, including the Ocular Surface Disease Index questionnaire, tear break-up time, corneal fluorescein staining, lid margin abnormality grading, meibum expressibility and quality evaluations, Schirmer I test (SIT), as well as optical quality examinations using the Pentacam and Optical Quality Analysis System II, were conducted before and after the treatment.
124 eyes of 62 patients were included in the study. Most meibomian gland function and ocular surface parameters showed significant improvement after treatment. Except for and coma ( = .029), no other significant changes in optical quality were observed. Changes in SIT were significantly correlated with changes in total corneal high-order aberrations (tHOA-4mm) ( = -.224, = .019). Changes in objective scattering index were significantly associated with changes in spherical aberration ( = .219, = .022), trefoil ( = .797, < .001), total high-order aberrations ( = .408, < .001) and total corneal spherical aberration ( = .590, < .001).
Meibomian gland expression effectively improves meibomian gland function and ocular surface parameters. However, it does not appear to significantly impact optical quality in patients with MGD.
评估睑板腺功能障碍（MGD）患者睑板腺按摩前后睑板腺功能、眼表参数及光学质量的变化。
MGD患者连续4周每周进行1次睑板腺按摩。在治疗前后进行综合评估，包括眼表疾病指数问卷调查、泪膜破裂时间、角膜荧光素染色、睑缘异常分级、睑脂排出能力及质量评估、Schirmer I试验（SIT），以及使用Pentacam和光学质量分析系统II进行光学质量检查。
本研究纳入了62例患者的124只眼。治疗后大多数睑板腺功能和眼表参数有显著改善。除彗差（P = 0.029）外，未观察到光学质量的其他显著变化。SIT的变化与总角膜高阶像差（tHOA-4mm）的变化显著相关（P = -0.224，P = 0.019）。客观散射指数的变化与球差（P = 0.219，P = 0.022）、三叶草像差（P = 0.797，P < 0.001）、总高阶像差（P = 0.408，P < 0.001）和总角膜球差（P = 0.590，P < 0.001）的变化显著相关。
睑板腺按摩可有效改善睑板腺功能和眼表参数。然而，它似乎对MGD患者的光学质量没有显著影响。
