El-Morsy Osama Abd Allah, Ramadan Hasnaa Hosam Eldin, Fayed Ahmed Shebl
Ophthalmology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.
Int Ophthalmol. 2025 May 8;45(1):180. doi: 10.1007/s10792-025-03534-1.
The aim of this study was to assess the tear film and meibomian gland function before and after cataract surgery using the Lacrydiag ocular surface analyzer.
This was an observational prospective study including 34 eyes that underwent phacoemulsification at the Ophthalmology Department of Menoufia University Hospital from October 2023 to January 2024. The patients were evaluated pre-operatively as well as 1 week, 1 month, and 3 months postoperatively. Dry eye symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Traditional tear break up time (TBUT) was performed as well as Schirmer I test. The Lacrydiag Ocular Surface Analyzer was used for assessment of the tear film and meibomian glands.
Ocular surface analyzer evaluations revealed statistically significant changes at 1 week, 1 month, and 3 months after surgery in comparison to the values before surgery. Significant reductions were observed in non-invasive tear break-up time (NITBUT) and tear meniscus height, as well as in Schirmer's test without anesthesia, and fluorescein break-up time at each postoperative interval. Some improvements were observed at 1 month and 3 months, however, measurements did not return to the initial preoperative levels. Ocular Surface Disease Index (OSDI) scores significantly increased after 1 week, 1 month, and 3 months post-surgery compared to preoperative levels. The proportion of meibomian gland area loss did not significantly increase after surgery (no structural alterations were noted).
The study shows that phacoemulsification impacts both tear quantity and quality, affecting overall tear film stability and ocular surface health.
本研究旨在使用Lacrydiag眼表分析仪评估白内障手术前后的泪膜和睑板腺功能。
这是一项观察性前瞻性研究,纳入了2023年10月至2024年1月在曼努菲亚大学医院眼科接受超声乳化手术的34只眼睛。对患者进行术前以及术后1周、1个月和3个月的评估。使用眼表疾病指数(OSDI)问卷评估干眼症状。进行传统的泪膜破裂时间(TBUT)以及泪液分泌试验I。使用Lacrydiag眼表分析仪评估泪膜和睑板腺。
眼表分析仪评估显示,与手术前的值相比,术后1周、1个月和3个月有统计学上的显著变化。在每个术后时间段,非侵入性泪膜破裂时间(NITBUT)、泪河高度、无麻醉下的泪液分泌试验以及荧光素破裂时间均显著降低。在1个月和3个月时观察到一些改善,然而,测量值并未恢复到术前初始水平。与术前水平相比,术后1周、1个月和3个月时眼表疾病指数(OSDI)评分显著增加。术后睑板腺面积损失比例没有显著增加(未观察到结构改变)。
该研究表明,超声乳化手术会影响泪液的量和质,影响整体泪膜稳定性和眼表健康。