Kidwell-Chandler Ariel, Jackson Justin, Jeng Brenda, Silveira Stephanie L, Pilutti Lara A, Hibbing Paul R, Motl Robert W
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Department of Management, Policy, and Community Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Nutrients. 2025 Mar 14;17(6):1021. doi: 10.3390/nu17061021.
: There is emerging interest in obesity and its prevalence, outcomes, and management in people with multiple sclerosis (MS). Body mass index (BMI) is the traditional marker of obesity in MS, whereas body composition, inclusive of specific body tissue compartments (e.g., fat, bone, and muscle), is often overlooked despite its relevance. This narrative review (a) underscored the use and utility of dual-energy X-ray absorptiometry (DEXA) as an accurate and reliable measure of body composition; (b) thematically analyzed and synthesized the current evidence regarding body composition (using DEXA); and (c) determined gaps to be addressed in future research. : The structure and reporting of this narrative review followed the guiding criteria outlined in the Scale for the Assessment of Narrative Review Articles (SANRA). The relevant literature for this narrative review was identified via a PubMed search utilizing combined search terms such as 'body composition' and 'multiple sclerosis'. The identified research was then organized by the authors into major themes and sub-themes. The articles described within the narrative review were based on saturation of the identified themes and sub-themes. : Three major themes were identified, namely (1) comparison of body composition between people with MS and non-MS controls (2 meta-analyses); (2) examination of the relationships between body composition and a range of outcomes (14 cross-sectional studies); and (3) interventions that report and/or target body composition in MS (11 clinical trials). : This narrative review mapped the existing evidence regarding body composition in MS, and posits body composition as a novel, informative, and targeted concept for this population. The narrative review underscores the importance of randomized controlled trials that focus on body composition as a significant and modifiable outcome. Such research could improve the understanding of obesity and poor body composition in MS and identify useful clinical recommendations for diagnosis and management.
人们对肥胖及其在多发性硬化症（MS）患者中的患病率、后果和管理的兴趣日益浓厚。体重指数（BMI）是MS中肥胖的传统标志物，而身体成分，包括特定的身体组织部分（如脂肪、骨骼和肌肉），尽管具有相关性，但常常被忽视。本叙述性综述（a）强调了双能X线吸收法（DEXA）作为一种准确可靠的身体成分测量方法的应用和效用；（b）对有关身体成分（使用DEXA）的现有证据进行了主题分析和综合；（c）确定了未来研究中需要解决的差距。：本叙述性综述的结构和报告遵循了《叙述性综述文章评估量表》（SANRA）中概述的指导标准。通过PubMed搜索，利用“身体成分”和“多发性硬化症”等组合搜索词确定了本叙述性综述的相关文献。然后，作者将所确定的研究组织成主要主题和子主题。叙述性综述中描述的文章基于所确定主题和子主题的饱和度。：确定了三个主要主题，即（1）MS患者与非MS对照者身体成分的比较（2项荟萃分析）；（2）身体成分与一系列后果之间关系的研究（14项横断面研究）；以及（3）报告和/或针对MS身体成分的干预措施（11项临床试验）。：本叙述性综述梳理了关于MS患者身体成分的现有证据，并将身体成分定位为该人群的一个新颖、信息丰富且具有针对性的概念。叙述性综述强调了以身体成分为重要且可改变结局的随机对照试验的重要性。此类研究可以增进对MS患者肥胖和身体成分不佳的理解，并确定有用的诊断和管理临床建议。
Zotero 插件