Department of Occupational Therapy, University of Alabama at Birmingham, Birmingham, AL, USA; UAB/Lakeshore Research Collaborative, Birmingham, AL, USA.
UAB/Lakeshore Research Collaborative, Birmingham, AL, USA.
Disabil Health J. 2018 Apr;11(2):243-248. doi: 10.1016/j.dhjo.2017.10.003. Epub 2017 Oct 16.
Persons with multiple sclerosis (MS) have many health conditions related to overweight and obesity, but little is known about how body composition among those with MS compares to those without MS at the same weight.
To compare differences in whole body and regional body composition between persons with and without MS matched for sex and body mass index (BMI).
Persons with MS (n = 51) and non-MS controls (n = 51) matched for sex and BMI. Total mass, lean mass, fat mass, and percent body fat (%BF) of total body and arm, leg, and trunk segments were assessed using dual-energy X-ray absorptiometry (DXA).
Men with MS had significantly less whole body lean mass (mean difference: 9933.5 ± 3123.1 g, p < 0.01) and higher fat mass (mean difference: 6079.0 ± 2137.4 g, p = .01) and %BF (mean difference: 9.43 ± 2.04%, p < 0.01) than BMI-matched non-MS counterparts. Further, men with MS had significantly lower lean mass in the arm (p = 0.02) and leg (p < 0.01) and higher fat mass in the arm (p = 0.01), leg (p = 0.03) and trunk (p = 0.03) than men without MS. Men with MS had significantly higher %BF in all three regions (p < 0.01) than men without MS. There were no differences between women with and without MS.
We observed significant differences in whole body and regional body composition between BMI-matched men with and without MS. Additional research is needed to further explore differences in body composition, adipose distribution, and the impact of these differences on the health and function of men with MS.
多发性硬化症（MS）患者有许多与超重和肥胖相关的健康状况，但对于 MS 患者与同体重的非 MS 患者相比，其身体成分有何不同，知之甚少。
比较性别和体重指数（BMI）匹配的 MS 患者和非 MS 患者全身和局部身体成分的差异。
选择 MS 患者（n=51）和非 MS 对照组（n=51），按性别和 BMI 匹配。采用双能 X 射线吸收法（DXA）评估全身及手臂、腿部和躯干各节段的总质量、瘦组织质量、脂肪质量和体脂肪百分比（%BF）。
MS 男性的全身瘦组织质量明显较少（平均差异：9933.5±3123.1g，p<0.01），脂肪质量较高（平均差异：6079.0±2137.4g，p=0.01），体脂肪百分比较高（平均差异：9.43±2.04%，p<0.01），与 BMI 匹配的非 MS 对照组相比。此外，MS 男性手臂（p=0.02）和腿部（p<0.01）的瘦组织质量明显较低，手臂（p=0.01）、腿部（p=0.03）和躯干（p=0.03）的脂肪质量明显较高，非 MS 男性。MS 男性在所有三个区域的 %BF 均明显较高（p<0.01），而非 MS 男性。女性 MS 患者与非 MS 患者之间无差异。
我们观察到 BMI 匹配的 MS 男性和非 MS 男性在全身和局部身体成分方面存在显著差异。需要进一步研究以进一步探讨身体成分、脂肪分布以及这些差异对 MS 男性健康和功能的影响。
