Just H M, Becker C, Gieringer J, Wenz A, Bassler M, Daschner F
Drugs. 1985;29 Suppl 5:74-7. doi: 10.2165/00003495-198500295-00015.
The in vitro efficacy of temocillin in combination with ticarcillin and with gentamicin, tobramycin, amikacin and netilmicin against 80 Gram-negative and 20 Gram-positive bacterial strains was compared by use of the checkerboard agar dilution technique. No synergistic or additive effect was seen on the Gram-positive strains. Great variations occurred between the different bacterial species, and the temocillin-ticarcillin combination had only little effect against the Pseudomonas strains tested. On average, only 12% of all strains tested were inhibited synergistically by temocillin-gentamicin combinations, and only 7 to 10% by combinations of temocillin with the other aminoglycosides. However, 25% of Gram-negative strains were inhibited synergistically and 40% of Gram-negative strains were inhibited additively by the combination of temocillin-gentamicin.
采用棋盘琼脂稀释技术比较了替莫西林与替卡西林联合以及与庆大霉素、妥布霉素、阿米卡星和奈替米星联合对80株革兰氏阴性菌和20株革兰氏阳性菌的体外抗菌效果。对革兰氏阳性菌未观察到协同或相加作用。不同细菌种类之间存在很大差异，替莫西林 - 替卡西林联合对所测试的假单胞菌菌株几乎没有作用。平均而言，所有测试菌株中只有12%被替莫西林 - 庆大霉素联合用药协同抑制，替莫西林与其他氨基糖苷类药物联合用药协同抑制的比例仅为7%至10%。然而，替莫西林 - 庆大霉素联合用药可协同抑制25%的革兰氏阴性菌，相加抑制40%的革兰氏阴性菌。
