Zhu Jun-Kun, Wang Jing
Department of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong Province, China.
World J Clin Oncol. 2025 Apr 24;16(4):101548. doi: 10.5306/wjco.v16.i4.101548.
The cytochrome P450 3A () gene family's role in early progression of gastric cancer was comprehensively investigated. Its potential as a therapeutic target was evaluated. Upon literature review, aberrant expression of the gene family has a strong correlation with gastric cancer onset, although the precise underlying mechanisms remain unclear. To assess its potential as a biomarker for early diagnosis and a therapeutic target, we have provided a comprehensive review of the regulatory mechanisms governing gene family expression in gastric cancer, as well as its relation with early tumor progression and the tumor microenvironment. The gene family is crucial in the proliferation, migration, and invasion of gastric cancer cells and promotes cancer progression by modulating inflammatory responses and oxidative stress within the tumor microenvironment. Furthermore, genetic polymorphisms in enzymes highlight its potential value in personalized medicine. Based on these findings, this paper explores the feasibility of developing inhibitors and activators targeting enzymes and discusses potential applications in gene therapy. This research provides crucial theoretical support for the gene family as an early diagnostic marker and therapeutic target for gastric cancer. In the future, multi-omics studies and large-scale clinical trials will be essential to advance clinical translation of these findings.
细胞色素P450 3A（）基因家族在胃癌早期进展中的作用得到了全面研究。评估了其作为治疗靶点的潜力。经文献综述，该基因家族的异常表达与胃癌发病密切相关，尽管确切的潜在机制尚不清楚。为了评估其作为早期诊断生物标志物和治疗靶点的潜力，我们全面综述了胃癌中该基因家族表达的调控机制，以及其与肿瘤早期进展和肿瘤微环境的关系。该基因家族在胃癌细胞的增殖、迁移和侵袭中起关键作用，并通过调节肿瘤微环境中的炎症反应和氧化应激促进癌症进展。此外，酶的基因多态性凸显了其在个性化医疗中的潜在价值。基于这些发现，本文探讨了开发靶向该酶的抑制剂和激活剂的可行性，并讨论了在基因治疗中的潜在应用。本研究为该基因家族作为胃癌的早期诊断标志物和治疗靶点提供了关键的理论支持。未来，多组学研究和大规模临床试验对于推进这些发现的临床转化至关重要。
