Department of Clinical Pharmacy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq; Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan Region, Iraq.
Department of Clinical Pharmacy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq; Pharmacy department, School of Medicine, University of Kurdistan Hewlêr (UKH), Erbil, Kurdistan Region, Iraq.
Pathol Res Pract. 2024 Jun;258:155328. doi: 10.1016/j.prp.2024.155328. Epub 2024 Apr 23.
Gastric cancer continues to have a high death rate despite advancements in their diagnosis and treatment. Novel treatment techniques are thus desperately needed. This is where double-stranded RNA molecules known as small interfering RNA (siRNA), which may selectively target the mRNA of disease-causing genes, may find use in medicine. For siRNAs to function properly in the human body, they must be shielded from deterioration. Furthermore, in order to maintain organ function, they must only target the tumor and spare normal tissue. siRNAs have been designed using clever delivery mechanisms including polymers and lipids to achieve these objectives. Although siRNA protection is not hard to acquire, it is still challenging to target cancer cells with them. Here, we first discuss the basic characteristics of gastric cancer before describing the properties of siRNA and typical delivery methods created specifically for gastric tumors. Lastly, we provide a succinct overview of research using siRNAs to treat gastric tumors.
尽管在胃癌的诊断和治疗方面取得了进展，但胃癌的死亡率仍然很高。因此，非常需要新的治疗技术。这就是双链 RNA 分子，即小干扰 RNA（siRNA），可以选择性地靶向致病基因的 mRNA，可能在医学上得到应用。为了使 siRNA 在人体内正常发挥作用，必须对其进行保护，防止其降解。此外，为了维持器官功能，它们必须只针对肿瘤，而不针对正常组织。已经设计了使用聚合物和脂质等巧妙的递药机制的 siRNA，以实现这些目标。尽管 siRNA 的保护并不难获得，但用它们靶向癌细胞仍然具有挑战性。在这里，我们首先讨论了胃癌的基本特征，然后描述了 siRNA 的特性和专门针对胃癌肿瘤的典型递药方法。最后，我们简要概述了使用 siRNA 治疗胃癌肿瘤的研究。
