Monteiro Luís M, Gouveia Pedro J, Vasques-Nóvoa Francisco, Rosa Susana, Bardi Ifigeneia, Gomes Rita N, Correia-Santos Simão, Ricotti Leonardo, Vannozzi Lorenzo, Guarnera Daniele, Costa Liliana, Leite-Moreira André M, Mendes-Ferreira Pedro, Leite-Moreira Adelino F, Perbellini Filippo, Terracciano Cesare M, Pinto-do-Ó Perpétua, Ferreira Lino, Nascimento Diana S
IIIUC-Institute of Interdisciplinary Research, University of Coimbra, Casa Costa Alemão, 3030-789, Coimbra, Portugal.
CNC-Center for Neuroscience and Cell Biology, CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, UC, Biotech Parque Tecnológico de Cantanhede, 3060-197, Coimbra, Portugal.
Mater Today Bio. 2025 Apr 9;32:101742. doi: 10.1016/j.mtbio.2025.101742. eCollection 2025 Jun.
Ischemic heart disease is the leading cause of death worldwide. Several approaches have been explored to restore cardiac function, however few investigated new strategies to improve electrical functional recovery. Herein, we have investigated the impact of piezoelectric patches (Piezo patches), capable of generating electric charges upon mechanical deformation, on rat cardiac slices, healthy and ischemic hearts (), on infarcted mice () and on healthy and infarcted pigs (). Piezo patches did not preclude cardiac slice contractility, while compared with electrically inert control patches. In addition, Piezo patches showed an adequate safety profile in a working heart model as no electrophysiologic alterations were detected in healthy hearts. Epicardial implantation of Piezo patches in acutely infarcted mice hearts significantly improved myocardial electrical integrity without disturbing systolic function. Moreover, Piezo patches partially prevented ischemia-related adverse cardiac remodeling, reducing left ventricular chamber dilatation and compensatory hypertrophy. Coherently, Piezo patch-implanted hearts revealed downregulation of genes associated with extracellular matrix remodeling. Importantly, implantation of Piezo patches in porcine hearts revealed to be electrically safe as no major effects in its electrophysiology were detected. Overall, the results presented here endorse Piezo patches as a promising therapeutic strategy to improve post-myocardial infarction structural and electrical remodeling.
缺血性心脏病是全球主要的死亡原因。人们已经探索了多种恢复心脏功能的方法，然而很少有人研究改善电功能恢复的新策略。在此，我们研究了能够在机械变形时产生电荷的压电贴片对大鼠心脏切片、健康和缺血心脏（）、梗死小鼠（）以及健康和梗死猪（）的影响。与电惰性对照贴片相比，压电贴片并不妨碍心脏切片的收缩性。此外，在工作心脏模型中，压电贴片显示出良好的安全性，因为在健康心脏中未检测到电生理改变。在急性梗死小鼠心脏中的心外膜植入压电贴片可显著改善心肌电完整性，而不影响收缩功能。此外，压电贴片部分预防了缺血相关的不良心脏重塑，减少了左心室扩张和代偿性肥大。一致地，植入压电贴片的心脏显示与细胞外基质重塑相关的基因下调。重要的是，在猪心脏中植入压电贴片被证明在电方面是安全的，因为未检测到对其电生理的重大影响。总体而言，此处呈现的结果支持压电贴片作为一种有前景的治疗策略，以改善心肌梗死后的结构和电重塑。
