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抑制KLK8可通过恢复VE-钙黏蛋白/Akt/FOXM1信号通路促进肺内皮修复。

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring the VE-cadherin/Akt/FOXM1 pathway.

作者信息

Zhao Ying, Ji Hui, Han Feng, Xu Qing-Feng, Zhang Hui, Liu Di, Wei Juan, Xu Dan-Hong, Jiang Lai, Du Jian-Kui, Xu Ping-Bo, Liu Yu-Jian, Zhu Xiao-Yan

机构信息

School of Kinesiology, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.

Department of Physiology, Navy Medical University, Shanghai, 200433, China.

出版信息

J Pharm Anal. 2025 Apr;15(4):101153. doi: 10.1016/j.jpha.2024.101153. Epub 2024 Nov 23.

DOI:10.1016/j.jpha.2024.101153
PMID:40291017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12032894/
Abstract

Image 1.

摘要

图1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/12032894/9d158e952658/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/12032894/5eeb12532536/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/12032894/9d158e952658/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/12032894/5eeb12532536/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/12032894/9d158e952658/gr1.jpg

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J Pharm Anal. 2025 Apr;15(4):101153. doi: 10.1016/j.jpha.2024.101153. Epub 2024 Nov 23.
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本文引用的文献

1
Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury.内皮细胞 FoxM1 可重新激活衰老损伤的内皮细胞再生,促进血管修复和炎症性肺损伤的消退。
Sci Transl Med. 2023 Aug 16;15(709):eabm5755. doi: 10.1126/scitranslmed.abm5755.
2
Endothelial progenitor cells in the host defense response.宿主防御反应中的内皮祖细胞。
Pharmacol Ther. 2023 Jan;241:108315. doi: 10.1016/j.pharmthera.2022.108315. Epub 2022 Nov 24.
3
Remodelling of the tumour microenvironment by the kallikrein-related peptidases.
激肽释放酶相关肽酶重塑肿瘤微环境。
Nat Rev Cancer. 2022 Apr;22(4):223-238. doi: 10.1038/s41568-021-00436-z. Epub 2022 Jan 31.
4
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.激肽释放酶相关肽酶8在糖尿病性心脏纤维化发病机制中的新作用
Theranostics. 2021 Feb 20;11(9):4207-4231. doi: 10.7150/thno.48530. eCollection 2021.
5
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.小鼠中VE-钙黏蛋白基因的靶向缺失或胞质截断会损害VEGF介导的内皮细胞存活和血管生成。
Cell. 1999 Jul 23;98(2):147-57. doi: 10.1016/s0092-8674(00)81010-7.