鸡清道夫受体的标准化基因命名法。

Standardized Gene Nomenclature for Chicken Scavenger Receptors.

作者信息

Kirkpatrick Coltton, McCarthy Fiona

机构信息

College of Animal Comparative and Biomedical Sciences, University of Arizona, Tucson, Arizona, United States.

出版信息

MicroPubl Biol. 2025 Apr 11;2025. doi: 10.17912/micropub.biology.001559. eCollection 2025.

DOI:10.17912/micropub.biology.001559

PMID:40291052

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12032555/

Abstract

Scavenger Receptors (SCARs) are a heterogeneous group involved in innate immunity and immunomodulation. We provided standardized nomenclature for chicken SCAR genes in line with other vertebrate nomenclatures. Chicken SCAR genes orthologous to human genes are assigned the same gene names and symbols. Novel SCAR genes were assessed to determine their appropriate class and assigned nomenclature in line with this classification. Notably, chicken has expansions of the MRC and DMBT genes, and the number of these paralogs varies across Sauropsida species. In addition, we identified and classified a further 15 novel SCAR genes, predominantly SCAR class I genes.

摘要

清道夫受体（SCARs）是参与天然免疫和免疫调节的一组异质性分子。我们根据其他脊椎动物的命名法为鸡的SCAR基因提供了标准化命名。与人类基因直系同源的鸡SCAR基因被赋予相同的基因名称和符号。对新的SCAR基因进行评估，以确定其合适的类别，并根据该分类赋予命名。值得注意的是，鸡的MRC和DMBT基因存在扩增，这些旁系同源基因的数量在蜥形纲物种中有所不同。此外，我们还鉴定并分类了另外15个新的SCAR基因，主要是SCAR I类基因。