Sami Chowdhury Adnan, Rahaman Mohammad Ferdous Ur, Khan Md Mizanur Rahman, Alam Bhuiyan Mohammad Monzurul, Matin Md Abdul, Rashed Hasan M, Khan Abed H, Arafat Shohael Mahmud, Hasan Md Nazmul
Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.
Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.
Cureus. 2025 Mar 26;17(3):e81225. doi: 10.7759/cureus.81225. eCollection 2025 Mar.
Background Despite being typically a viral respiratory disease, COVID-19 has harmful effects that go beyond the respiratory system. The endocrine system is particularly susceptible to damage due to the high expression of angiotensin-converting enzyme-2 receptors. This study evaluates glycemic status in survivors of COVID-19. Methodology In this prospective, observational study, 96 individuals were enrolled from the COVID-19 unit of Bangabandhu Sheikh Mujib Medical University (BSMMU). Mild and moderate COVID-19 patients were classified as non-severe, whereas severe and critical cases were classified as severe, following the WHO disease severity classification. Follow-ups were conducted at the post-COVID-19 clinic at BSMMU one and six months after diagnosis. Blood samples for fasting blood sugar and glycated hemoglobin measurements were collected within 24 hours of initial diagnosis and during each follow-up at the first and sixth months. Results Of the 96 participants, the non-severe and severe groups consisted of 49 (51%) and 47 (49%) participants, respectively. Among the participants, 62 (63.9%) were men, the mean age was 54.2 (15.9) years, and hypertension was the most common comorbidity (37, 38.5%). After six months, 12 new cases of diabetes (15.4%) were observed, with a male predominance (10, 62%). After adjusting for potential confounders, we found that severe COVID-19 was substantially linked to a higher risk of diabetes at six months (odds ratio = 5.5, 95% confidence interval, 1.1-27.7, p = 0.03). Conclusions The study findings showed a significant association between a higher frequency of diabetes and severe COVID-19.
尽管新冠病毒病通常是一种病毒性呼吸道疾病，但其有害影响超出了呼吸系统。由于血管紧张素转换酶2受体的高表达，内分泌系统特别容易受到损害。本研究评估了新冠病毒病幸存者的血糖状况。方法：在这项前瞻性观察研究中，从孟加拉国谢赫·穆吉布医学大学（BSMMU）的新冠病毒病治疗单元招募了96名个体。按照世界卫生组织的疾病严重程度分类，轻度和中度新冠病毒病患者被归类为非重症，而重度和危重症病例被归类为重症。在诊断后1个月和6个月，于BSMMU的新冠病毒病后诊所进行随访。在初次诊断后24小时内以及第1个月和第6个月的每次随访时，采集用于测量空腹血糖和糖化血红蛋白的血样。结果：96名参与者中，非重症组和重症组分别有49名（51%）和47名（49%）参与者。参与者中，62名（63.9%）为男性，平均年龄为54.2（15.9）岁，高血压是最常见的合并症（37例，38.5%）。6个月后，观察到12例新发糖尿病病例（15.4%），男性占主导（10例，62%）。在对潜在混杂因素进行调整后，我们发现重症新冠病毒病与6个月时患糖尿病的较高风险显著相关（比值比=5.5，95%置信区间，1.1 - 27.7，p = 0.03）。结论：研究结果显示糖尿病的较高发生率与重症新冠病毒病之间存在显著关联。
