Impact of Low-Energy and High-Energy Early Enteral Nutrition Strategies on Patient Outcomes in Acute Kidney Injury.

OBJECTIVE

To investigate the impact of different early enteral nutrition (EEN) strategies on nutritional indicators and immune function in patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).

METHODS

A retrospective analysis was conducted on 60 CRRT-treated AKI patients from January 2020 to March 2024, divided into a control group (high-energy EEN) and an observation group (low-energy EEN). Nutritional indicators (albumin, prealbumin, hemoglobin), immune function indicators (CD4+, CD8+, immunoglobulin A, G, M), and clinical outcomes (ICU stay duration, CRRT duration, gastric retention) were compared.

RESULTS

Before treatment, there were no significant differences in nutritional indicators between the two groups (P > 0.05). After 7 days of treatment, the observation group showed significantly greater improvements in all nutritional indicators (P < 0.05). Immune function indicators also improved significantly in the observation group (P < 0.05). Additionally, the observation group had significantly shorter ICU and CRRT durations compared to the control group (P < 0.05).

CONCLUSION

Compared to high-energy EEN guidance, low-energy EEN guidance significantly improves nutritional status and enhances immune function in CRRT-treated AKI patients.