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低能量与高能量早期肠内营养策略对急性肾损伤患者预后的影响

Impact of Low-Energy and High-Energy Early Enteral Nutrition Strategies on Patient Outcomes in Acute Kidney Injury.

作者信息

Hou Ajuan, Zhao Caiping

机构信息

Department of Nephrology, Xianyang Central Hospital, Xianyang, 712000, People's Republic of China.

出版信息

Int J Gen Med. 2025 Apr 21;18:2207-2215. doi: 10.2147/IJGM.S505545. eCollection 2025.

DOI:10.2147/IJGM.S505545
PMID:40291399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12024476/
Abstract

OBJECTIVE

To investigate the impact of different early enteral nutrition (EEN) strategies on nutritional indicators and immune function in patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).

METHODS

A retrospective analysis was conducted on 60 CRRT-treated AKI patients from January 2020 to March 2024, divided into a control group (high-energy EEN) and an observation group (low-energy EEN). Nutritional indicators (albumin, prealbumin, hemoglobin), immune function indicators (CD4+, CD8+, immunoglobulin A, G, M), and clinical outcomes (ICU stay duration, CRRT duration, gastric retention) were compared.

RESULTS

Before treatment, there were no significant differences in nutritional indicators between the two groups (P > 0.05). After 7 days of treatment, the observation group showed significantly greater improvements in all nutritional indicators (P < 0.05). Immune function indicators also improved significantly in the observation group (P < 0.05). Additionally, the observation group had significantly shorter ICU and CRRT durations compared to the control group (P < 0.05).

CONCLUSION

Compared to high-energy EEN guidance, low-energy EEN guidance significantly improves nutritional status and enhances immune function in CRRT-treated AKI patients.

摘要

目的

探讨不同早期肠内营养（EEN）策略对接受连续性肾脏替代治疗（CRRT）的急性肾损伤（AKI）患者营养指标和免疫功能的影响。

方法

对2020年1月至2024年3月期间60例接受CRRT治疗的AKI患者进行回顾性分析，分为对照组（高能EEN）和观察组（低能EEN）。比较营养指标（白蛋白、前白蛋白、血红蛋白）、免疫功能指标（CD4 +、CD8 +、免疫球蛋白A、G、M）和临床结局（ICU住院时间、CRRT持续时间、胃潴留）。

结果

治疗前，两组营养指标差异无统计学意义（P > 0.05）。治疗7天后，观察组所有营养指标改善均更显著（P < 0.05）。观察组免疫功能指标也显著改善（P < 0.05）。此外，观察组ICU和CRRT持续时间均显著短于对照组（P < 0.05）。

结论

与高能EEN指导相比，低能EEN指导可显著改善接受CRRT治疗的AKI患者的营养状况并增强免疫功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/3d40e5ebb413/IJGM-18-2207-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/53374b409991/IJGM-18-2207-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/bb7b61dc8bbc/IJGM-18-2207-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/9d833e5c75ac/IJGM-18-2207-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/3d40e5ebb413/IJGM-18-2207-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/53374b409991/IJGM-18-2207-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/bb7b61dc8bbc/IJGM-18-2207-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/9d833e5c75ac/IJGM-18-2207-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/12024476/3d40e5ebb413/IJGM-18-2207-g0004.jpg

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本文引用的文献

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Early continuous renal replacement therapy in septic acute kidney injury could be defined by its initiation within 24 hours of vasopressor infusion.脓毒症急性肾损伤的早期连续性肾脏替代治疗可定义为在血管升压药输注后24小时内开始治疗。
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