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伴HER2扩增的乳腺黏液性囊腺癌的基因组及临床病理特征：1例报告

Genomic and clinical‑pathological features of mucinous cystadenocarcinoma of the breast with HER2 amplification: A case report.

作者信息

Liu Liling, Li Mingxian, Qiu Xinmin, Zheng Xirun, Zheng Guangjuan, Yang Haifeng

机构信息

Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China.

出版信息

Oncol Lett. 2025 Apr 16;29(6):304. doi: 10.3892/ol.2025.15050. eCollection 2025 Jun.

DOI:10.3892/ol.2025.15050
PMID:40291475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12030918/
Abstract

Mucinous cystadenocarcinoma (MCA) of the breast is a rare, invasive carcinoma that resembles pancreatobiliary or ovarian MCA in terms of histological appearance. Most cases of MCA of the breast are negative for the estrogen receptor, progesterone receptor and ERBB2 (HER2). To the best of our knowledge, only five reports of HER2-positive MCA cases have been reported in the English language, and no reports focusing on the molecular characteristics of HER2-positive MCAs have been published. In the present study, a rare case of a 64-year-old woman with HER2-positive MCA who underwent long-term follow-up without recurrence or distant metastasis is reported. In addition, a detailed analysis of the genomic characteristics of the tumor is provided.

摘要

乳腺黏液性囊腺癌（MCA）是一种罕见的浸润性癌，在组织学表现上类似于胰胆管或卵巢MCA。大多数乳腺MCA病例的雌激素受体、孕激素受体和ERBB2（HER2）均为阴性。据我们所知，英文文献中仅报道了5例HER2阳性MCA病例，且尚未发表聚焦于HER2阳性MCA分子特征的报告。在本研究中，报告了1例64岁HER2阳性MCA女性患者，该患者接受了长期随访，无复发或远处转移。此外，还提供了对该肿瘤基因组特征的详细分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/12030918/755ac87ca518/ol-29-06-15050-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/12030918/795a1e71a95f/ol-29-06-15050-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/12030918/755ac87ca518/ol-29-06-15050-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/12030918/795a1e71a95f/ol-29-06-15050-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/12030918/755ac87ca518/ol-29-06-15050-g01.jpg

相似文献

[1]
Genomic and clinical‑pathological features of mucinous cystadenocarcinoma of the breast with HER2 amplification: A case report.

Oncol Lett. 2025-4-16

[2]
Mixed primary mucinous cystadenocarcinoma and invasive ductal carcinoma of the breast: a case report and literature review.

Transl Cancer Res. 2022-12

[3]
HER2-positive mucinous cystadenocarcinoma of the breast coexisting with invasive lobular carcinoma: A case report and review of the literature.

Diagn Cytopathol. 2024-9

[4]
Mucinous cystadenocarcinoma of breast in a 69-year-old woman with positive hormone receptors, the first case reported.

Caspian J Intern Med. 2021

[5]
Primary Mucinous Cystadenocarcinoma of the Breast Intermixed with Pleomorphic Invasive Lobular Carcinoma: The First Report of This Rare Association.

J Pers Med. 2023-6-3

[6]
Primary mammary mucinous cystadenocarcinoma: cytological and histological findings.

Diagn Cytopathol. 2012-7

[7]
Primary mucinous cystadenocarcinoma of the breast with amplification of the HER2 gene confirmed by FISH - case report and review of the literature.

Pol J Pathol. 2014-3

[8]
Mammary synchronous mucinous cystadenocarcinoma and columnar cell mucinous carcinoma: a case report.

Int J Clin Exp Pathol. 2020-9-1

[9]
Mammary mucinous cystadenocarcinoma with long-term follow-up: molecular information and literature review.

Diagn Pathol. 2023-2-4

[10]
Imaging Characteristics of Primary Mucinous Cystadenocarcinoma of the Breast: A Case Report and Literature Review.

Curr Med Imaging. 2025

本文引用的文献

[1]
Primary mucinous cystadenocarcinoma of the breast: A case report and literature review.

Oncol Lett. 2024-11-15

[2]
HER2-positive mucinous cystadenocarcinoma of the breast coexisting with invasive lobular carcinoma: A case report and review of the literature.

Diagn Cytopathol. 2024-9

[3]
Mucinous cystadenocarcinoma of the breast harbours TRPS1 expressions and PIK3CA alterations.

Histopathology. 2024-2

[4]
Primary breast mucinous cystadenocarcinoma-histopathological analysis.

Transl Cancer Res. 2023-2-28

[5]
Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?

Biomolecules. 2023-2-11

[6]
Mammary mucinous cystadenocarcinoma with long-term follow-up: molecular information and literature review.

Diagn Pathol. 2023-2-4

[7]
Mucinous cystadenocarcinoma of the breast: a new entity with broad differentials-a case report.

J Egypt Natl Canc Inst. 2022-2-28

[8]
The clinicopathological and prognostic significances of LATS1 expression in breast cancer.

Histol Histopathol. 2022-7

[9]
Genetic profile of primary mucinous cystadenocarcinoma of the breast-A case report.

Breast J. 2021-9

[10]
CDK12: an emerging therapeutic target for cancer.

J Clin Pathol. 2018-8-13

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