Saurborn Emily, Noorbakhsh Seth, Enoch Jenna, Cortes Raul, McClellan William
From the Joan C. Edwards School of Medicine, Marshall University, Huntington, WV.
Division of Plastic Surgery, Rutgers New Jersey Medical School, Newark, NJ.
Plast Reconstr Surg Glob Open. 2025 Apr 25;13(4):e6713. doi: 10.1097/GOX.0000000000006713. eCollection 2025 Apr.
The purpose of this study was to analyze the effect of autologous fat transfer on outcomes in patients with basilar thumb arthritis.
Twenty-three patients with carpometacarpal (CMC) arthritis underwent autologous fat transfer under fluoroscopic guidance. Autologous fat was harvested from the abdomen and separated with nonadherent gauze (Telfa). After processing, 2 mL of fat was injected into the CMC joint. All patients were placed in a prefabricated thermoplastic splint for 2 weeks postoperatively. Patients completed the Disability of Arm-Shoulder-Hand Questionnaire (DASH) questionnaire both preoperatively and postoperatively at 1, 6, and 12 months. Paired tests were used to compare pretreatment to posttreatment DASH scores. Significance was set at a value less than 0.05 (95% confidence interval [CI]).
The average preoperative DASH score was 51.81 (95% CI, 45.85-57.76). Average postoperative DASH score at 1-month follow-up was 26.16 (95% CI, 19.76-32.57), followed by a DASH score at 6-month follow-up of 22.49, 95% CI (15.41-29.54), and a DASH score at 12-month follow-up of 26.62 (95% CI, 17.68-35.56). Improvements in DASH score were as follows: 26.49 at 1 month postoperatively ( < 0.01), 30.64 at 6 months postoperatively ( < 0.01), and 26.89 at 12 months postoperatively ( < 0.01). No major adverse events were observed.
Autologous fat transfer for the treatment of CMC osteoarthritis significantly improved hand function in our cohort. Additional studies of fat transfer are warranted to better understand the physiologic mechanisms and therapeutic benefits.
本研究旨在分析自体脂肪移植对基底节拇指关节炎患者治疗效果的影响。
23例腕掌关节（CMC）关节炎患者在透视引导下接受自体脂肪移植。自体脂肪取自腹部，并用非粘性纱布（泰尔弗）分离。处理后，将2毫升脂肪注入CMC关节。所有患者术后均佩戴预制热塑性夹板2周。患者在术前以及术后1个月、6个月和12个月完成手臂-肩膀-手部功能障碍问卷（DASH）。采用配对检验比较治疗前和治疗后DASH评分。显著性设定为P值小于0.05（95%置信区间[CI]）。
术前DASH评分平均为51.81（95%CI，45.85 - 57.76）。1个月随访时术后DASH评分平均为26.16（95%CI，19.76 - 32.57），6个月随访时DASH评分为22.49，95%CI（15.41 - 29.54），12个月随访时DASH评分为26.62（95%CI，17.68 - 35.56）。DASH评分改善情况如下：术后1个月为26.49（P < 0.01），术后6个月为30.64（P < 0.01），术后12个月为26.89（P < 0.01）。未观察到重大不良事件。
自体脂肪移植治疗CMC骨关节炎显著改善了我们队列中患者的手部功能。有必要对脂肪移植进行更多研究，以更好地了解其生理机制和治疗益处。
