Ulvenstam G, Aberg A, Bergstrand R, Johansson S, Pennert K, Vedin A, Wedel H, Wilhelmsen L, Wilhelmsson C
Eur Heart J. 1985 Apr;6(4):294-302. doi: 10.1093/oxfordjournals.eurheartj.a061856.
1306 men below 68 years of age who survived a first myocardial infarction (MI) during 1968-1977 were followed up between 2 and 12 years after discharge from hospital. The mean follow-up time was 6.5 years. The patients were unselected and paid regular visits to a Post-MI Clinic where treatment was standardized. The diagnosis of a non-fatal reinfarction was based on conventional clinical criteria, and the diagnosis of a fatal reinfarction on autopsy findings of a recent myocardial injury and/or a fresh coronary thrombus. The autopsy rate was high and the follow-up of endpoints was complete. The total cumulative rate of endpoint free patients was 64% at 5 years and 50% at 10 years follow-up. The total mortality rate was 19% at 5 years and 33% at 10 years follow-up. The total cumulative rate of a first reinfarction was 28% at 5 years and 37% at 10 years follow-up (80% non-fatal and 20% fatal). 63 patients suffered more than one reinfarction. The mortality rate was strongly associated with age. In contrast the rate of non-fatal reinfarctions was independent of age.
1968年至1977年间首次发生心肌梗死（MI）且存活下来的1306名68岁以下男性患者在出院后2至12年接受了随访。平均随访时间为6.5年。这些患者未经筛选，定期前往心肌梗死后诊所就诊，那里的治疗是标准化的。非致命性再梗死的诊断基于传统临床标准，致命性再梗死的诊断基于近期心肌损伤和/或新鲜冠状动脉血栓的尸检结果。尸检率很高，终点随访完整。随访5年时无终点事件患者的累计总率为64%，随访10年时为50%。随访5年时总死亡率为19%，随访10年时为33%。随访5年时首次再梗死的累计总率为28%，随访10年时为37%（80%为非致命性，20%为致命性）。63名患者发生了不止一次再梗死。死亡率与年龄密切相关。相比之下，非致命性再梗死的发生率与年龄无关。
