深部脑刺激治疗缺氧后肌阵挛：一例将局部场电位与临床结果相关联的病例
Deep Brain Stimulation for Post-Hypoxic Myoclonus: A Case Correlating Local Field Potentials to Clinical Outcome.
作者信息
Kaur Harleen, Goble Tim J, Fenoy Albert, Ramdhani Ritesh A
机构信息
Department of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, USA.
Medtronic Neuromodulation, Medtronic, Minneapolis, MN, USA.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2025 Apr 24;15:16. doi: 10.5334/tohm.999. eCollection 2025.
BACKGROUND
Post-hypoxic myoclonus (PHM) is characterized by generalized myoclonus after hypoxic brain injury. PHM is often functionally impairing and refractory to medical therapies. There are a handful of reports utilizing deep brain stimulation (DBS) to treat medically refractory PHM.
CASE REPORT
A 56-year-old woman developed PHM following an anoxic brain injury. Utilizing a stimulating and sensing DBS system, we show clinical improvement in myoclonus at 6 months and correlate it to local field potential (LFP) activity.
DISCUSSION
We present the first case to utilize DBS sensing to correlate LFP activity to myoclonus improvement. Our case contributes to the growing evidence of DBS for PHM.
背景
缺氧后肌阵挛（PHM）的特征是缺氧性脑损伤后出现全身性肌阵挛。PHM通常会导致功能障碍，且对药物治疗无效。有少数关于利用深部脑刺激（DBS）治疗药物难治性PHM的报道。
病例报告
一名56岁女性在缺氧性脑损伤后出现PHM。我们使用了一种具有刺激和传感功能的DBS系统，结果显示6个月时肌阵挛有临床改善，并将其与局部场电位（LFP）活动相关联。
讨论
我们展示了首例利用DBS传感将LFP活动与肌阵挛改善相关联的病例。我们的病例为DBS治疗PHM的证据不断增加做出了贡献。
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