Department of Neurology, Movement Disorders and Neuromodulation Center, Weill Institute of Neurosciences, University of California, San Francisco, San Francisco, CA, US.
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, US.
Tremor Other Hyperkinet Mov (N Y). 2020 Oct 13;10:42. doi: 10.5334/tohm.544.
Post-hypoxic myoclonus (PHM) is characterized by generalized myoclonus after hypoxic brain injury. Myoclonus is often functionally impairing and refractory to medical therapies. Deep brain stimulation (DBS) has been used to treat myoclonus-dystonia, but few cases of PHM have been described.
A 33-year-old woman developed severe, refractory generalized myoclonus after cardiopulmonary arrest from drowning. We performed MRI-guided asleep bilateral pallidal DBS placement, resulting in improvement in action myoclonus at one year.
Our case contributes to growing evidence for DBS for PHM. Interventional MRI guided DBS technique can be used for safe and accurate lead placement.
We report a case of a patient who developed post-hypoxic myoclonus after cardiopulmonary arrest from drowning, who later underwent deep brain stimulation to treat refractory myoclonus. This is the first case to describe asleep, interventional MRI-guided technique for implanting DBS leads in post-hypoxic myoclonus.
低氧后肌阵挛（PHM）的特征是缺氧性脑损伤后出现全身肌阵挛。肌阵挛常导致功能障碍，且对药物治疗有抗性。深部脑刺激（DBS）已被用于治疗肌阵挛-肌张力障碍，但很少有 PHM 病例的描述。
一名 33 岁女性因心肺骤停溺水后出现严重、难治性全身肌阵挛。我们进行了 MRI 引导下双侧苍白球 DBS 植入，一年后运动性肌阵挛得到改善。
我们的病例为 DBS 治疗 PHM 提供了更多证据。介入性 MRI 引导 DBS 技术可用于安全、准确地放置导联。
我们报告了一例心肺骤停溺水后发生低氧后肌阵挛的患者，后来接受了深部脑刺激治疗难治性肌阵挛。这是首例描述在低氧后肌阵挛中使用介入性 MRI 引导技术植入 DBS 导联的病例。
