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丘脑深部脑刺激治疗围产期缺氧所致动作性肌阵挛

Thalamic deep brain stimulation for the treatment of action myoclonus caused by perinatal anoxia.

作者信息

Kobayashi Kazutaka, Katayama Yoichi, Otaka Toshiharu, Obuchi Toshiki, Kano Toshikazu, Nagaoka Takafumi, Kasai Masahiko, Oshima Hideki, Fukaya Chikashi, Yamamoto Takamitsu

机构信息

Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Stereotact Funct Neurosurg. 2010;88(4):259-63. doi: 10.1159/000315464. Epub 2010 Jun 8.

DOI:10.1159/000315464
PMID:20530980
Abstract

BACKGROUND

Perinatal anoxia rarely causes myoclonus as the main neurologic abnormality. The exact neuronal mechanism underlying myoclonus induced by perinatal anoxia remains unknown. Some studies have indicated that the development of involuntary movements may be related to the maturation of the thalamus after birth.

OBJECTIVES AND METHODS

Here, we describe the first case of a patient who developed action myoclonus after experiencing perinatal anoxia and was successfully treated by chronic deep brain stimulation (DBS) of the thalamus (thalamic DBS).

RESULTS AND CONCLUSION

The effectiveness of chronic thalamic DBS in this patient supports the concept of involvement of the thalamus in post-perinatal anoxic myoclonus.

摘要

背景

围产期缺氧很少导致肌阵挛作为主要的神经学异常。围产期缺氧诱发肌阵挛的确切神经元机制仍不清楚。一些研究表明，不自主运动的发展可能与出生后丘脑的成熟有关。

目的和方法

在此，我们描述了首例围产期缺氧后发生动作性肌阵挛并通过丘脑慢性深部脑刺激（DBS）成功治疗的患者。

结果与结论

该患者慢性丘脑DBS的有效性支持了丘脑参与围产期缺氧后肌阵挛的观点。

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