Emeka N N, Ghasi S I, Sampson E, Erejuwa O O
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
Arch Razi Inst. 2024 Oct 31;79(5):943-948. doi: 10.32592/ARI.2024.79.5.943. eCollection 2024 Oct.
The role of postprandial hyperglycemia (PPH) has been identified as a contributing factor in the development of diabetes mellitus and its associated complications. The objective of this study was to investigate the effect of honey on high glucose-induced PPH in alloxan-induced diabetic rats. Diabetes mellitus was induced in overnight-fasted rats by administering alloxan [150 mg/kg body weight (BW)]. The diabetic rats were administered either drinking water (1 ml/kg BW) or honey (1, 2 or 3 g/kg BW) via oral gavage. Each group consisted of six rats. Prior to the administration of either the drinking water or the honey, the baseline fasting blood glucose (BG) was measured and recorded as BG. Subsequently, BG levels (BG, BG and BG) were assessed at 60, 120 and 180 minutes, respectively. The estimation of the BG parameters concentration was performed, including the area under the curve (AUC), the peak BG (PBG), the percentage change in BG. The AUC and PBG did not differ between the diabetic groups (regardless of administered agents) and the diabetic control group. Compared with baseline fasting blood glucose (BG), the BG significantly ( < 0.05) increased in diabetic rats that received drinking water or honey (2 or 3 g/kg BW) but not in diabetic rats that received 1 g/kg BW of honey. The diabetic rats that received 1 g/kg BW of honey exhibited significantly ( < 0.05) lower percentage change in BG compared with the diabetic control rats. The study demonstrated that the administration of honey (regardless of dosage) did not exacerbate high glucose-induced PPH in diabetic rats. The study also indicated that a dose of 1 g/kg BW of honey was the most effective dose in suppressing PPH.
餐后高血糖（PPH）的作用已被确定为糖尿病及其相关并发症发生发展的一个促成因素。本研究的目的是探讨蜂蜜对四氧嘧啶诱导的糖尿病大鼠高糖诱导的PPH的影响。通过给予四氧嘧啶[150mg/kg体重（BW）]，在禁食过夜的大鼠中诱导糖尿病。糖尿病大鼠通过口服灌胃给予饮用水（1ml/kg BW）或蜂蜜（1、2或3g/kg BW）。每组由6只大鼠组成。在给予饮用水或蜂蜜之前，测量并记录空腹血糖（BG）作为基线BG。随后，分别在60、120和180分钟时评估BG水平（BG、BG和BG）。进行了BG参数浓度的估计，包括曲线下面积（AUC）、BG峰值（PBG）、BG的变化百分比。糖尿病组（无论给予何种药物）和糖尿病对照组之间的AUC和PBG没有差异。与基线空腹血糖（BG）相比，接受饮用水或蜂蜜（2或3g/kg BW）的糖尿病大鼠的BG显著升高（<0.05），但接受1g/kg BW蜂蜜的糖尿病大鼠则没有。与糖尿病对照大鼠相比，接受1g/kg BW蜂蜜的糖尿病大鼠的BG变化百分比显著降低（<0.05）。该研究表明，给予蜂蜜（无论剂量如何）不会加重糖尿病大鼠高糖诱导的PPH。该研究还表明，1g/kg BW的蜂蜜剂量是抑制PPH最有效的剂量。
