Júnior Ivanildo I da S, Barbosa Humberto de Moura, Carvalho Débora C R, Barros Ruideglan de Alencar, Albuquerque Flávia Peixoto, da Silva Dionísio Henrique Amaral, Souza Grasielly R, Souza Nathália A C, Rolim Larissa A, Silva Flaviane M M, Duarte Glória I B P, Almeida Jackson R G da S, de Oliveira Júnior Flávio Monteiro, Gomes Dayane A, Lira Eduardo C
Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil.
Federal University of San Francisco Valley, Petrolina, PE, Brazil.
ScientificWorldJournal. 2017;2017:5275813. doi: 10.1155/2017/5275813. Epub 2017 Apr 16.
has been used popularly for several proposes, including diabetic. In an attempt to support medicinal value, the acute hypoglycemic, hypolipidemic, and antioxidant effects of the ethanolic extract of (EEMn 200 or 400 mg/kg b.w.) were evaluated in normal and alloxan-induced diabetic treated for 14 days. Serum biochemical and antioxidant analysis were performed at the end of experiment. Oral glucose tolerance test was performed at 10th and 15th days. Chromatographic analysis by HPLC-DAD of EEMn was performed. Insulin was used as positive control to glycemic metabolism as well as fenofibrate to lipid metabolism. EEMn (400 mg/kg/day) reduced fasting and postprandial glycaemia, improved oral glucose tolerance, and reduced lipolysis and proteolysis in diabetic rats. EEMn decreased the blood levels of total cholesterol and increased HDL level when compared to the diabetic control rats. At higher levels, EEMn reduced triglycerides and VLDL levels in diabetic rats. Also, EEMn reduced malondialdehyde and increased the reduced glutathione levels in liver of diabetic rats. Chromatographic analysis identified the presence of the flavonoids rutin, isoquercetin, and kaempferitrin. Acute EEMn treatment reduced hyperglycemia, improved oral glucose tolerance, and minimized dyslipidemia and oxidative stress leading to a reduction in atherogenic index in alloxan-induced diabetic rats.
它已被广泛用于多种目的，包括糖尿病方面。为了支持其药用价值，对（EEMn 200或400毫克/千克体重）乙醇提取物在正常和四氧嘧啶诱导的糖尿病大鼠中进行了为期14天的急性降血糖、降血脂和抗氧化作用评估。实验结束时进行血清生化和抗氧化分析。在第10天和第15天进行口服葡萄糖耐量试验。对EEMn进行了HPLC-DAD色谱分析。胰岛素用作血糖代谢的阳性对照，非诺贝特用作脂质代谢的阳性对照。EEMn（400毫克/千克/天）降低了糖尿病大鼠的空腹和餐后血糖，改善了口服葡萄糖耐量，并减少了脂解和蛋白水解。与糖尿病对照大鼠相比，EEMn降低了总胆固醇的血液水平并提高了高密度脂蛋白水平。在较高剂量时，EEMn降低了糖尿病大鼠的甘油三酯和极低密度脂蛋白水平。此外，EEMn降低了糖尿病大鼠肝脏中的丙二醛水平并提高了还原型谷胱甘肽水平。色谱分析确定了黄酮类化合物芦丁、异槲皮素和山柰酚的存在。急性EEMn治疗降低了高血糖，改善了口服葡萄糖耐量，并使四氧嘧啶诱导的糖尿病大鼠的血脂异常和氧化应激降至最低，从而导致动脉粥样硬化指数降低。
