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产后11年垂体影像显现:晚期席汉综合征一例报告

Unmasking the pituitary shadow 11 years postpartum: A case report of late-stage Sheehan's syndrome.

作者信息

Mesbah Oumaima, Messaoud Ola, Kabila Badr, El Aoufir Omar, Jroundi Laila, Houssaini Zaynab Iraqi

机构信息

Emergency Radiology Department, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat, Morocco.

出版信息

Radiol Case Rep. 2025 Apr 12;20(7):3267-3270. doi: 10.1016/j.radcr.2025.03.027. eCollection 2025 Jul.

DOI:10.1016/j.radcr.2025.03.027
PMID:40292129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12018080/
Abstract

Sheehan's syndrome (SS) is a rare but significant condition that occurs as a result of postpartum pituitary gland infarction, typically following severe blood loss or hypotension during or after childbirth. The syndrome is characterized by signs of anterior pituitary insufficiency, including deficiencies in hormones such as cortisol, thyroid hormones, and gonadotropins. The diagnosis of this rare but potentially fatal disease is often delayed due to the vague symptoms and the insidious nature of pituitary dysfunction. It is typically confirmed through hormonal assays and imaging, which reveal anatomical changes in the pituitary gland, such as atrophy or empty sella syndrome, supporting the diagnosis. Treatment of Sheehan's syndrome primarily involves hormone replacement therapy to correct the endocrine imbalances, to prevent adrenal crises and other complications. We present the case of a 40-year-old woman, 11 years postpartum, who was hospitalized for a severe infection, revealing a pituitary dysfunction due to a delayed revelation of Sheehan's syndrome.

摘要

席汉综合征(SS)是一种罕见但严重的病症,它是产后垂体梗死的结果,通常发生在分娩期间或之后的严重失血或低血压之后。该综合征的特征是垂体前叶功能减退的体征,包括皮质醇、甲状腺激素和促性腺激素等激素缺乏。由于症状模糊以及垂体功能障碍的隐匿性,这种罕见但可能致命的疾病的诊断常常延迟。通常通过激素检测和影像学检查来确诊,这些检查可揭示垂体的解剖学变化,如萎缩或空蝶鞍综合征,从而支持诊断。席汉综合征的治疗主要包括激素替代疗法,以纠正内分泌失衡,预防肾上腺危象和其他并发症。我们报告一例产后11年的40岁女性病例,该患者因严重感染住院,结果发现因席汉综合征发现延迟而导致垂体功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/347e/12018080/3538f51bf392/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/347e/12018080/3538f51bf392/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/347e/12018080/3538f51bf392/gr1.jpg

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本文引用的文献

1
A Case of Sheehan Syndrome Six Years Postpartum Presented With Adrenal Crisis and Complicated by Hypothyroidism and Massive Pericardial Effusion.产后六年席汉综合征一例,伴肾上腺危象,并发甲状腺功能减退和大量心包积液。
Cureus. 2023 Jan 19;15(1):e33972. doi: 10.7759/cureus.33972. eCollection 2023 Jan.
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Sheehan Syndrome: An Unusual Presentation Without Inciting Factors.希恩综合征:一种无诱发因素的不典型表现。
Womens Health Rep (New Rochelle). 2020 Aug 24;1(1):287-292. doi: 10.1089/whr.2019.0028. eCollection 2020.
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Extensive investigation of 114 patients with Sheehan's syndrome: a continuing disorder.
对 114 例席汉氏综合征患者的广泛调查:一种持续性疾病。
Eur J Endocrinol. 2014 Sep;171(3):311-8. doi: 10.1530/EJE-14-0244. Epub 2014 Jun 10.
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Assessment of bleeding disorders in Sheehan's syndrome: are bleeding disorders the underlying cause of Sheehan's syndrome?希恩氏综合征中的出血性疾病评估:出血性疾病是否为希恩氏综合征的根本病因?
Platelets. 2011;22(2):92-7. doi: 10.3109/09537104.2010.525722. Epub 2010 Dec 6.
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Gynecol Endocrinol. 2006 May;22(5):279-83. doi: 10.1080/09513590600630504.
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Demonstration of reserved anterior pituitary function among patients with amenorrhea after postpartum hemorrhage.产后出血后闭经患者垂体前叶储备功能的表现
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Salient clinical features of Sheehan's syndrome.席汉综合征的显著临床特征。
J Med Assoc Thai. 1989 Jan;72(1):41-7.