Shih W J, Tatum J L, Burke T S
Eur J Nucl Med. 1985;10(11-12):554-6. doi: 10.1007/BF00252752.
A 99mTc-sulfur colloid (99mTc-SC) scintigraphic study of a patient with pancreatic carcinoma invading the splenic hilum demonstrated a discrete focal defect of the spleen, while computed tomography (CT) showed a normal spleen. The patient underwent splenectomy and no pathology was found in the spleen. The tumor invasion into the splenic hilum may have caused the defect shown in the 99mTC-SC study, reflecting splenic reticuloendothelial (RE) cell dysfunction, while CT might well represent anatomic structures only. This discrepant finding between functional (99mTc-SC) and anatomic (CT) imaging modalities may be explained by the fact that the impairment of the phagocytic function of the spleen apparently was not severe enough to cause structural changes detected by CT or gross and microscope examination.
对一名胰腺癌侵犯脾门的患者进行的99m锝-硫胶体（99mTc-SC）闪烁扫描研究显示脾脏有一个离散的局灶性缺损，而计算机断层扫描（CT）显示脾脏正常。该患者接受了脾切除术，脾脏未发现病理改变。肿瘤侵犯脾门可能导致了99mTc-SC研究中显示的缺损，反映了脾网状内皮（RE）细胞功能障碍，而CT可能仅代表解剖结构。功能成像（99mTc-SC）和解剖成像（CT）方式之间的这种差异发现可能是由于脾脏吞噬功能的损害显然不够严重，不足以引起CT检测到的结构变化或大体及显微镜检查发现的变化。
