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药物-聚合物系统的可编程性质及其影响

The Programmable Nature of Drug-Polymer Systems and Its Implications.

作者信息

Ghizdovat Vlad, Nica Irina, Ochiuz Lacramioara, Popa Ovidiu, Vasincu Decebal, Rusu Dragos Ioan, Agop Maricel, Trofin Ana-Maria

机构信息

Biophysics and Medical Physics Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700050 Iași, Romania.

Department of Odontology-Periodontology, Fixed Prosthesis, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

出版信息

Polymers (Basel). 2025 Mar 12;17(6):745. doi: 10.3390/polym17060745.

DOI:10.3390/polym17060745
PMID:40292610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11944507/
Abstract

In our work, we use the multifractal motion theory to apply a multifractal state density conservation law to the polymer-drug release process. This law is specific to the transition from multifractal to nonmultifractal curves corresponding to the polymer-drug release processes. A multifractal diffusion-type law was obtained, which describes the cyclic drug release dynamics until the polymer matrix is fully degraded. The polymer-drug system reveals a programmable nature due to its complex part and scale resolution dependence.

摘要

在我们的工作中，我们运用多重分形运动理论，将多重分形态密度守恒定律应用于聚合物-药物释放过程。该定律特定于聚合物-药物释放过程中从多重分形曲线到非多重分形曲线的转变。我们得到了一个多重分形扩散型定律，它描述了直到聚合物基质完全降解的循环药物释放动力学。由于其复杂的部分和对尺度分辨率的依赖性，聚合物-药物系统呈现出可编程的特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/c06309f54c94/polymers-17-00745-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/aeaa57c674a3/polymers-17-00745-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/1a29e9b2af57/polymers-17-00745-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/0a07a0d5c536/polymers-17-00745-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/44bb6286931b/polymers-17-00745-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/ba07549cc2e7/polymers-17-00745-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/c06309f54c94/polymers-17-00745-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/aeaa57c674a3/polymers-17-00745-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/1a29e9b2af57/polymers-17-00745-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/0a07a0d5c536/polymers-17-00745-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/44bb6286931b/polymers-17-00745-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/ba07549cc2e7/polymers-17-00745-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/c06309f54c94/polymers-17-00745-g006.jpg

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本文引用的文献

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A Holographic-Type Model in the Description of Polymer-Drug Delivery Processes.聚合物药物递送过程描述中的一种全息型模型。
Pharmaceuticals (Basel). 2024 Apr 22;17(4):541. doi: 10.3390/ph17040541.
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Weibull β value for the discernment of drug release mechanism of PLGA particles.Weibull β 值用于判别 PLGA 粒子的药物释放机制。
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Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles.多尺度分形模型研究姜黄素从聚合物胶束中的释放机制。
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Chem Soc Rev. 2022 Mar 7;51(5):1558-1572. doi: 10.1039/d1cs00587a.
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Targeted drug delivery strategies for precision medicines.精准药物的靶向给药策略。
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Hybrid gels by conjugation of hyaluronic acid with poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5)undecane) copolymers.通过将透明质酸与聚（衣康酸酐 - 共 - 3,9 - 二乙烯基 - 2,4,8,10 - 四氧杂螺[5.5]十一烷）共聚物共轭制备的杂化凝胶。
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Multifunctional nanogels with dual temperature and pH responsiveness.具有双重温度和pH响应性的多功能纳米凝胶
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Patterning poly(maleic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer bioconjugates for controlled release of drugs.用于药物控释的聚（马来酸酐 - 共 - 3,9 - 二乙烯基 - 2,4,8,10 - 四氧杂螺[5.5]十一烷）共聚物生物共轭物的图案化
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