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药物-聚合物系统的可编程性质及其影响

The Programmable Nature of Drug-Polymer Systems and Its Implications.

作者信息

Ghizdovat Vlad, Nica Irina, Ochiuz Lacramioara, Popa Ovidiu, Vasincu Decebal, Rusu Dragos Ioan, Agop Maricel, Trofin Ana-Maria

机构信息

Biophysics and Medical Physics Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700050 Iași, Romania.

Department of Odontology-Periodontology, Fixed Prosthesis, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

出版信息

Polymers (Basel). 2025 Mar 12;17(6):745. doi: 10.3390/polym17060745.

Abstract

In our work, we use the multifractal motion theory to apply a multifractal state density conservation law to the polymer-drug release process. This law is specific to the transition from multifractal to nonmultifractal curves corresponding to the polymer-drug release processes. A multifractal diffusion-type law was obtained, which describes the cyclic drug release dynamics until the polymer matrix is fully degraded. The polymer-drug system reveals a programmable nature due to its complex part and scale resolution dependence.

摘要

在我们的工作中,我们运用多重分形运动理论,将多重分形态密度守恒定律应用于聚合物-药物释放过程。该定律特定于聚合物-药物释放过程中从多重分形曲线到非多重分形曲线的转变。我们得到了一个多重分形扩散型定律,它描述了直到聚合物基质完全降解的循环药物释放动力学。由于其复杂的部分和对尺度分辨率的依赖性,聚合物-药物系统呈现出可编程的特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0158/11944507/aeaa57c674a3/polymers-17-00745-g001.jpg

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