缓激肽可拮抗大鼠体内吗啡诱导的镇痛作用。
Bradykinin antagonizes morphine-induced analgesia in rats.
作者信息
Argiolas A, Melis M R, Gessa G L
出版信息
Eur J Pharmacol. 1985 Jun 7;112(2):277-80. doi: 10.1016/0014-2999(85)90510-2.
PMID:4029262
Abstract
The intraventricular injection of 5 micrograms of bradykinin or Met-Lys-bradykinin in rats antagonized the increase in nociception threshold induced by morphine (5 micrograms i.c.v. or 10 mg/kg i.p.) in the tail flick test. The effect of the two kinins was prevented by atropine (30 mg/kg i.p.). The results suggest that bradykinin counteracts opiate activity in the central nervous system by enhancing acetylcholine release.
摘要
给大鼠脑室内注射5微克缓激肽或甲硫氨酸 - 赖氨酸 - 缓激肽，可拮抗吗啡（脑室内注射5微克或腹腔注射10毫克/千克）在甩尾试验中诱导的痛觉阈值升高。两种激肽的作用可被阿托品（腹腔注射30毫克/千克）阻断。结果表明，缓激肽通过增强乙酰胆碱释放来抵消中枢神经系统中的阿片类活性。
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