Richardson T M, Marks M S, Ausprunk D H, Miller M
Exp Eye Res. 1985 Jul;41(1):31-51. doi: 10.1016/0014-4835(85)90092-2.
The cellular and tissue changes accompanying the development and growth of the aqueous outflow system of the cat were investigated by quantitative light microscopy and by scanning and transmission electron microscopy. As in primates, the trabecular beams and sheets of the cat aqueous outflow system developed by reorganization of cells and extracellular matrix within the tissue filling the anterior chamber angle recess. Enlargement and coalescence of intercellular spaces gave rise to intertrabecular channels. From 3 to 9 days after birth, communications were established between the anterior chamber and intertrabecular spaces by perforation and resorption of tissue which initially covered the angle apex and appeared to be a peripheral extension of Descement's membrane and the corneal endothelium. Macrophage-like cells could be involved in this process. A rapid increase in the volume of the intertrabecular spaces and in the number of trabecular cells coincided with the opening of the trabecular meshwork to the anterior chamber. The trabecular meshwork grew 150-fold in volume from birth to adulthood, mainly as a result of a similar-fold expansion of its connective tissue components. The volume of the intertrabecular spaces increased 24-fold and trabecular cell number increased 14-fold during this same period. The disproportionate increase in volume of the various components of the trabecular meshwork was responsible for the decreased cell density and rarefaction displayed by this tissue as development progressed. Development of the aqueous outflow system of the cat is thus a complex, but highly co-ordinated, process, that depends on continued proliferation of cells and extracellular matrix, a progressive ordering of these components, and selective atrophy and removal of specific tissue components.
通过定量光学显微镜以及扫描和透射电子显微镜，研究了猫房水流出系统发育和生长过程中伴随的细胞和组织变化。与灵长类动物一样，猫房水流出系统的小梁束和薄片是由填充前房角隐窝的组织内细胞和细胞外基质的重组发育而来的。细胞间隙的扩大和融合形成了小梁间通道。出生后3至9天，前房与小梁间间隙之间通过最初覆盖角尖的组织的穿孔和吸收建立了连通，该组织似乎是Descemet膜和角膜内皮的周边延伸。巨噬细胞样细胞可能参与了这一过程。小梁间间隙体积和小梁细胞数量的快速增加与小梁网向前房开放同时发生。从出生到成年，小梁网的体积增长了150倍，主要是由于其结缔组织成分有类似倍数的扩张。在同一时期，小梁间间隙的体积增加了24倍，小梁细胞数量增加了14倍。随着发育的进行，小梁网各成分体积的不成比例增加导致了该组织细胞密度降低和稀疏。因此，猫房水流出系统的发育是一个复杂但高度协调的过程，它依赖于细胞和细胞外基质的持续增殖、这些成分的逐步有序排列以及特定组织成分的选择性萎缩和清除。
