Maul E, Strozzi L, Muñoz C, Reyes C
Am J Ophthalmol. 1980 May;89(5):667-73. doi: 10.1016/0002-9394(80)90286-x.
We obtained specimens from the angle of the eye during a trabeculotomy-trabeculectomy operation of a 5-month-old boy with congenital glaucoma. Light and electron miscroscopy of the anterior chamber angle showed the presence of mesodermal tissue covering the entire trabecular area. The trabecular meshwork showed thickening of trabecular beams, and an increased amount of collagen fibrils in the trabecular matrix. Internal trabecular spaces contained red blood cells; outer trabecular spaces were not apparent. The juxtacanalicular trabecular meshwork was thicker than in normal cases, because of an increased amount of collagen fibrils. The endothelium of Schlemm's canal was underlined by a thick and constant layer of amorphous material. These observations suggested that the site of increased resistance to aqueous humor outflow in congenital glaucoma could be found in abnormalities of the trabecular meshwork and the internal wall of Schlemm's canal.
我们在一名患有先天性青光眼的5个月大男童的小梁切开-小梁切除术手术过程中，从眼内角度获取了标本。前房角的光镜和电镜检查显示，整个小梁区域覆盖有中胚层组织。小梁网显示小梁束增厚，小梁基质中的胶原纤维数量增加。小梁内部间隙含有红细胞；外部小梁间隙不明显。由于胶原纤维数量增加，近管区小梁网比正常情况更厚。施莱姆管的内皮细胞下有一层厚而持续的无定形物质。这些观察结果表明，先天性青光眼中房水流出阻力增加的部位可能存在于小梁网和施莱姆管内壁的异常中。
