Li Ping, Huang Zhisheng, Qin Yan, Liao Wenjian, Xiang Tianxin
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, P.R. China.
Jiang Xi Hospital of China-Japan Friendship Hospital, Nanchang, Jiangxi, P.R. China.
Future Sci OA. 2025 Dec;11(1):2497214. doi: 10.1080/20565623.2025.2497214. Epub 2025 Apr 28.
We present an atypical case of a 62-year-old female diagnosed with pulmonary mucosa-associated lymphoid tissue (p-MALT) lymphoma, which uniquely manifested as a singular cystic lesion in the lung. Diagnostic evaluations, including comprehensive imaging, bronchoscopy, and CT-guided lung biopsy, revealed this uncommon radiological presentation. Detailed histopathological and immunohistochemical assessments further supported the diagnosis. To determine the extent of the disease, systemic evaluations, such as whole-body PET-CT, gastroscopy, colonoscopy, and bone marrow biopsy, were conducted, confirming its localized nature. Following the definitive diagnosis, the patient underwent a rituximab-centric therapeutic regimen, which yielded significant clinical improvement. This case highlights the importance of recognizing distinctive cystic lung features in p-MALT lymphoma and the indispensable role of holistic diagnostic approaches in guiding precise therapeutic and prognostic decisions.
我们报告了一例非典型病例，一名62岁女性被诊断为肺黏膜相关淋巴组织（p-MALT）淋巴瘤，其独特表现为肺部单个囊性病变。包括全面影像学检查、支气管镜检查和CT引导下肺活检在内的诊断评估揭示了这种不常见的影像学表现。详细的组织病理学和免疫组织化学评估进一步支持了诊断。为确定疾病范围，进行了全身PET-CT、胃镜检查、结肠镜检查和骨髓活检等系统评估，证实其为局限性病变。明确诊断后，患者接受了以利妥昔单抗为中心的治疗方案，临床症状有显著改善。该病例强调了认识p-MALT淋巴瘤中独特的肺部囊性特征的重要性，以及整体诊断方法在指导精确治疗和预后决策中不可或缺的作用。
