Kou Lily, Huan Nai-Chien, Nyanti Larry Ellee, Chin Jiunn Sheng, Mohamad Nor Bahiyyah, Ramarmuty Hema Yamini
Department of Medicine Keningau Hospital Keningau Malaysia.
Department of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu Malaysia.
Respirol Case Rep. 2023 Jul 25;11(8):e01197. doi: 10.1002/rcr2.1197. eCollection 2023 Aug.
Pulmonary extra-nodal marginal zone B-cell lymphoma, also known as extra-nodal mucosa-associated lymphoid tissue (MALT) lymphoma, is rare among all non-Hodgkin lymphomas and generally among all pulmonary malignancies. We present a 46-year-old lady with persistent right lower lung consolidation despite earlier treatment efforts with intravenous antibiotics for community acquired pneumonia. Apart from initial presentation with a short 3-day history of fever, cough and shortness of breath, she had remained largely asymptomatic throughout the follow-up period. Flexible bronchoscopy done ruled out infectious aetiologies but transbronchial lung biopsies showed atypical lymphocytes. A computed tomography guided core biopsy of her right lung consolidation was subsequently performed, confirming a diagnosis of pulmonary MALT lymphoma. She was promptly referred to the haematology team for further management and commencement of chemotherapy. Pulmonary MALT lymphoma, albeit uncommon and often follows a relatively indolent cause, should be considered as a differential diagnosis among patients with persistent lung consolidation.
肺结外边缘区B细胞淋巴瘤，也称为结外黏膜相关淋巴组织（MALT）淋巴瘤，在所有非霍奇金淋巴瘤中较为罕见，在所有肺部恶性肿瘤中通常也较为罕见。我们报告一位46岁女性，尽管早期曾静脉使用抗生素治疗社区获得性肺炎，但右下肺持续实变。除了最初有3天的发热、咳嗽和呼吸急促病史外，在整个随访期间她基本无症状。进行的柔性支气管镜检查排除了感染性病因，但经支气管肺活检显示有非典型淋巴细胞。随后对其右肺实变进行了计算机断层扫描引导下的核心活检，确诊为肺MALT淋巴瘤。她被迅速转诊至血液科团队进行进一步治疗并开始化疗。肺MALT淋巴瘤虽然不常见且通常病程相对惰性，但在持续肺实变的患者中应考虑作为鉴别诊断。
