肺癌细胞系的球体形态与肿瘤学特征相关。
Spheroid morphology of lung cancer cell lines correlates with oncological profiles.
作者信息
Oishi Kaido, Matsumoto Keitaro, Hashimoto Shintaro, Uchida Fumitake, Hara Ryosuke, Nishimuta Masato, Matsumoto Takamune, Iwatake Mayumi, Tomoshige Koichi, Doi Ryoichiro, Machino Ryusuke, Obata Tomohiro, Nagayasu Takeshi
机构信息
Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Medical-Engineering Hybrid Professional Development Program, Nagasaki University, Nagasaki, Japan.
出版信息
Discov Oncol. 2025 Apr 28;16(1):627. doi: 10.1007/s12672-025-02132-y.
We assessed the correlation between Multicellular tumor spheroids (MCTS) morphology and the oncological profile of lung cancer cells. MCTS were generated in five lung cancer cell lines and classified into Type-A MCTS, which showed strong aggregation, and Type-B MCTS, which showed weak aggregation. Drug resistance was higher in Type-A MCTS, and invasive ability was higher in Type-B MCTS. The oncologic profile of lung cancer cell lines correlated with MCTS morphology. MCTS morphology could thus be used in basic oncology research and as a clinical prognostic tool.Registry and the Registration No. of the study/trial Not Applicable.
我们评估了多细胞肿瘤球体（MCTS）形态与肺癌细胞肿瘤学特征之间的相关性。在五种肺癌细胞系中生成了MCTS，并将其分为表现出强聚集性的A型MCTS和表现出弱聚集性的B型MCTS。A型MCTS的耐药性较高，而B型MCTS的侵袭能力较高。肺癌细胞系的肿瘤学特征与MCTS形态相关。因此，MCTS形态可用于基础肿瘤学研究和作为临床预后工具。研究/试验的注册机构和注册号：不适用。
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