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[β-肾上腺素能激动剂对豚鼠心室心肌溶酶体膜损伤程度和糖原磷酸化酶活性的作用]

[Action of beta-adrenomimetics on the degree of lysosomal membrane damage and glycogen phosphorylase activity of the ventricular myocardium of guinea pigs].

作者信息

Sysoliatina N A

出版信息

Farmakol Toksikol. 1988 Mar-Apr;51(2):59-61.

PMID:3378608
Abstract

The effects of partusisten, novodrin and nonachlazine on the acid phosphatase and glycogenphosphorylase activities in the guinea pig ventricle myocardium were studied. The injection of partusisten (1 mg/kg) significantly increased the acid phosphatase activity and preserved the strong negative correlation between the free activity of acid phosphatase seen in control animals and the "free activity/total activity" ratio. Beta adrenergic agonists exerted different effects on the "glycogenphosphorylase B activity/glycogenphosphorylase A + B activity" ratio.

摘要

研究了羟苄羟麻黄碱、新福林和氯乙双甲胺对豚鼠心室心肌中酸性磷酸酶和糖原磷酸化酶活性的影响。注射羟苄羟麻黄碱(1毫克/千克)可显著提高酸性磷酸酶活性,并保持对照动物中所见酸性磷酸酶游离活性与“游离活性/总活性”比值之间的强负相关。β肾上腺素能激动剂对“糖原磷酸化酶B活性/糖原磷酸化酶A + B活性”比值产生不同影响。

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