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[脂肪族麻醉剂(乙醚)和巴比妥酸盐(己烯醛)对总血流量和营养性血流量区域分布的影响]

[Effect of a fatty-series narcotic (ether) and a barbiturate (hexenal) on the regional distribution of the total and nutritive blood flow].

作者信息

Kovalev O A, Vanevskiĭ V L, Ivanova-Stoilova Ts M, Sheremetevskaia S K, Azarov V I

出版信息

Farmakol Toksikol. 1985 May-Jun;48(3):53-7.

PMID:4029382
Abstract

Inhalation of diethyl ether and intraperitoneal injection of hexenal in doses that provide a surgical state of anesthesia are accompanied by changes in the regional tone of the resistive blood vessels as well as by those in the ratio between the nutritive and shunting fractions of the blood flow in organs and tissues. The increase in the rate and enlargement of the area of transcapillary metabolism in the brain and myocardium (notwithstanding the decrease of the total blood flow in these organs) by means of the increased shunting fractions of the blood flow in vast skin and skeletal muscle areas are considered to be the most important events. Diethyl ether and hexenal cause different changes in the hepatic and renal hemodynamics.

摘要

吸入能产生外科麻醉状态剂量的乙醚以及腹腔注射己烯醛,会伴随着阻力血管局部张力的变化,以及器官和组织中血流营养部分与分流部分比例的变化。借助大面积皮肤和骨骼肌区域血流分流部分的增加,大脑和心肌中跨毛细血管代谢速率的提高和代谢面积的扩大(尽管这些器官的总血流量减少)被认为是最重要的事件。乙醚和己烯醛会引起肝脏和肾脏血流动力学的不同变化。

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