Walsh G M, Ferrone R A
Res Commun Chem Pathol Pharmacol. 1979 Apr;24(1):67-76.
The hypotensive effect of ether in rats was investigated by the direct Fick technique to determine whether hypotension was produced by reduced cardiac output or decreased total peripheral resistance. Relative to the conscious state, ether anesthesia decreased mean arterial pressure 9%, total peripheral resistance 47%, oxygen extraction 37%, and heart rate 7%; changes were qualitatively similar to those produced by hydralazine (0.5 mg/kg, i.v.) except that hydralazine did not decrease heart rate. These effects were no longer present two hours after withdrawal of ether. This study demonstrated that ether anesthesia in rats has a potent systemic arterial vasodilating action which is offset by increased cardiac output, resulting in mild hypotension.
采用直接菲克技术研究了乙醚对大鼠的降压作用，以确定低血压是由心输出量减少还是总外周阻力降低所致。与清醒状态相比，乙醚麻醉使平均动脉压降低了9%，总外周阻力降低了47%，氧摄取降低了37%，心率降低了7%；这些变化在性质上与肼屈嗪（0.5mg/kg，静脉注射）产生的变化相似，只是肼屈嗪不会降低心率。停止使用乙醚两小时后，这些作用不再存在。本研究表明，大鼠乙醚麻醉具有强大的全身动脉血管舒张作用，该作用被心输出量增加所抵消，从而导致轻度低血压。
