Jung Wu Chih, Ho Ya-Fang, Bai Li-Yuan, Wu Ching Feng, Chen Ting Ting, Wang Ya Jung
Chih Jung Wu.
Ya-Fang Ho.
Oncol Nurs Forum. 2025 Apr 23;52(3):191-204. doi: 10.1188/25.ONF.191-204.
To explore the trajectories of chemotherapy-induced peripheral neuropathy (CIPN) in lymphoma survivors and assess subdomains of CIPN in this population.
SAMPLE & SETTING: 80 newly diagnosed lymphoma survivors treated with R-CHOP were enrolled.
METHODS & VARIABLES: CIPN was assessed before chemotherapy (T1), after the first chemotherapy cycle (T2), after the fourth chemotherapy cycle (T3), after the completion of chemotherapy (T4), and 10 weeks post-treatment (T5). CIPN was measured using the Total Neuropathy Score clinical version and the MD Anderson Symptom Inventory.
Patients were categorized into high and low CIPN groups based on CIPN changes over time. The high CIPN group was older and experienced significantly more severe sensory peripheral neuropathy from T1 to T5, with the most severe symptoms observed at T4, followed by T3 and T5.
Healthcare providers should closely monitor older patients, those with pretreatment peripheral neuropathy symptoms, and those exhibiting pronounced sensory neuropathy during treatment to provide timely and effective symptom management, reducing the impact of CIPN.
探讨淋巴瘤幸存者化疗引起的周围神经病变（CIPN）的发展轨迹，并评估该人群中CIPN的各个子领域。
招募了80名接受R-CHOP治疗的新诊断淋巴瘤幸存者。
在化疗前（T1）、第一个化疗周期后（T2）、第四个化疗周期后（T3）、化疗结束后（T4）以及治疗后10周（T5）对CIPN进行评估。使用总神经病变评分临床版和MD安德森症状量表来测量CIPN。
根据CIPN随时间的变化，将患者分为CIPN高分组和低分组。CIPN高分组年龄较大，从T1到T5经历了明显更严重的感觉性周围神经病变，在T4时症状最严重，其次是T3和T5。
医疗保健提供者应密切监测老年患者、治疗前有周围神经病变症状的患者以及治疗期间表现出明显感觉性神经病变的患者，以便及时提供有效的症状管理，减轻CIPN的影响。
