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Sequence homologies among mitochondrial DNA-coded URF2, URF4 and URF5.

作者信息

Kikuno R, Miyata T

出版信息

FEBS Lett. 1985 Sep 9;189(1):85-8. doi: 10.1016/0014-5793(85)80847-4.

DOI:10.1016/0014-5793(85)80847-4
PMID:4029400
Abstract

Amino acid sequences coded for by 13 different genes of mammalian mitochondrial DNA (mtDNA) including 8 unassigned open reading frames (URFs) were compared in pairs. It was found that significant homologies exist among the amino acid sequences of the three URFs (URF2, URF4 and URF5) with a probability of occurrence of less than 10(-5). This result strongly suggests that the 3 URFs evolved from a single ancestral gene by a series of gene duplications. A phylogenetic tree based on the alignment of the URF sequences from mammals, an insect, a fungus and protozoa revealed a very remote divergence of the 3 URFs, going back to a time before separations of animal/protozoa and animal/fungus.

摘要

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