Poon W W, McCoshen J A
Fertil Steril. 1985 Sep;44(3):361-5. doi: 10.1016/s0015-0282(16)48861-8.
A cervical factor accounts for 5% to 10% of infertility among women. In the absence of an immunologic or endocrine-related basis for incompetent sperm/mucus interaction, an idiopathic cause is usually ascribed. This study describes quantitative analyses of the microstructure of mucin strands, observed under scanning electron microscopy, from infertile women displaying incompetent sperm/mucus interaction unrelated to any apparent immunologic or endocrine-associated cause. The results revealed a highly significant reduction in the spacing of mucin fibers incompatible to sperm penetrability and migration. Additional quantitative measurements of mucin strand diameter and number and geometry of strand crosslinks suggest inadequate hydration of the mucin gel as a causative basis for the structural inadequacies observed in some cases of cervical-factor infertility.
宫颈因素导致的女性不孕占不孕病例的5%至10%。在不存在精子/黏液相互作用异常的免疫或内分泌相关基础的情况下，通常归因于特发性原因。本研究描述了对不孕女性黏液素纤维束微观结构的定量分析，这些女性表现出精子/黏液相互作用异常，且与任何明显的免疫或内分泌相关原因无关，分析是在扫描电子显微镜下进行的。结果显示，与精子穿透和迁移不相容的黏液素纤维间距显著减小。对黏液素纤维束直径、数量以及纤维束交联几何形状的额外定量测量表明，黏液素凝胶水化不足是某些宫颈因素不孕病例中观察到的结构缺陷的致病基础。
