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卵巢癌患者中保留生育功能手术的候选者

Candidates for Fertility-Sparing Surgery in Case of Ovarian Cancer.

作者信息

Gracia Myriam, Alonso-Espías María, Zapardiel Ignacio

机构信息

Gynecologic Oncology Unit, La Paz University Hospital, Madrid, Spain.

出版信息

Semin Reprod Med. 2025 Apr 28. doi: 10.1055/s-0045-1808243.

Abstract

Ovarian cancer, a leading cause of gynecological cancer mortality, often affects women of reproductive age. Fertility-sparing surgery (FSS) has emerged as a viable option for selected patients with early-stage ovarian cancer who wish to preserve fertility. Patient and tumor selection criteria focus on preserving ovarian function and reproductive potential without compromising oncological safety. Optimal candidates are young, premenopausal women with disease confined to one ovary and favorable prognostic factors such as early FIGO stage, specific histologic subtypes, and good overall health. FSS typically involves unilateral salpingo-oophorectomy while preserving the uterus and contralateral ovary, achieving survival outcomes comparable to radical surgery in early-stage low-grade tumors. However, its application in higher-risk cases requires cautious evaluation. Multidisciplinary management, involving gynecologic oncologists and reproductive specialists, is essential for successful implementation of FSS, ensuring both oncological safety and preservation of reproductive potential. Long-term follow-up is critical to monitor recurrence and assess reproductive outcomes. Pregnancy after FSS is feasible, with timing guided by cancer type, stage, and individual circumstances. This review summarizes the current knowledge on FSS in ovarian cancer, emphasizing its relevance and the need for further research to refine patient selection and ensure optimal outcomes.

摘要

卵巢癌是导致妇科癌症死亡的主要原因之一,常影响育龄女性。对于希望保留生育能力的特定早期卵巢癌患者,保留生育功能手术(FSS)已成为一种可行的选择。患者和肿瘤的选择标准侧重于在不影响肿瘤学安全性的前提下保留卵巢功能和生殖潜能。最佳候选者是疾病局限于一侧卵巢、具有良好预后因素(如国际妇产科联盟(FIGO)早期分期、特定组织学亚型和总体健康状况良好)的年轻绝经前女性。FSS通常包括单侧输卵管卵巢切除术,同时保留子宫和对侧卵巢,在早期低级别肿瘤中可实现与根治性手术相当的生存结果。然而,其在高风险病例中的应用需要谨慎评估。多学科管理,包括妇科肿瘤学家和生殖专家,对于FSS的成功实施至关重要,可确保肿瘤学安全性和生殖潜能的保留。长期随访对于监测复发和评估生殖结局至关重要。FSS术后怀孕是可行的,时机由癌症类型、分期和个体情况决定。本综述总结了目前关于卵巢癌FSS的知识,强调了其相关性以及进一步研究以完善患者选择并确保最佳结局的必要性。

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