Dooley C P, Reznick J B, Valenzuela J E
Gastroenterology. 1985 Oct;89(4):821-6. doi: 10.1016/0016-5085(85)90578-5.
Previous manometric studies of the pylorus in humans have yielded conflicting data. These interstudy variations may be the result of differences in technique. It is also possible that pyloric pressure shows cyclic variations with the interdigestive motility complex. Pyloric pressure was monitored continuously for 300 min in 6 healthy men by means of a Dent sleeve. Gastroduodenal activity was measured simultaneously by using a perfused catheter system with two antral and two duodenal ports. With this method the pylorus was shown to have no elevation in basal pressure above baseline duodenal pressure during phase III. Basal pyloric pressure varied between subjects in phases I and II, being elevated in some but not in others. Subjects restudied on a separate day often showed a different pattern of activity. Pyloric pressure increased gradually in response to duodenal acidification. This response was blocked by pretreatment with naloxone. The pylorus also showed phasic activity, which was maximal in phase III. This phasic activity could not be distinguished from that of the adjacent antrum and duodenum. In conclusion, pyloric pressure patterns showed marked variation within and between subjects. These variations may explain some of the differences between previous studies.
先前对人类幽门的测压研究得出了相互矛盾的数据。这些研究间的差异可能是技术差异所致。幽门压力也有可能随着消化间期移行性复合运动出现周期性变化。通过丹特套管对6名健康男性的幽门压力进行了300分钟的连续监测。同时使用带有两个胃窦端口和两个十二指肠端口的灌注导管系统测量胃十二指肠活动。用这种方法显示，在第三期，幽门的基础压力并未高于十二指肠基线压力。在第一期和第二期，不同受试者的幽门基础压力有所不同，部分受试者升高，部分则未升高。在另一天重新接受研究的受试者常常表现出不同的活动模式。幽门压力会因十二指肠酸化而逐渐升高。这种反应可被纳洛酮预处理阻断。幽门还表现出阶段性活动，在第三期最为明显。这种阶段性活动与相邻胃窦和十二指肠的活动并无差异。总之，幽门压力模式在受试者内部和受试者之间均表现出显著差异。这些差异可能解释了先前研究之间的一些不同之处。
