通过气管内接种增强仓鼠体内奥密克戎BA.1的致病性。
Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation.
作者信息
Port Julia R, Yinda Claude Kwe, Ruckel Claire, Schulz Jonathan E, Smith Brian J, Shaia Carl I, Munster Vincent J
机构信息
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
出版信息
Npj Viruses. 2024 Jan 16;2(1):3. doi: 10.1038/s44298-023-00012-2.
The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的奥密克戎BA.1变体经鼻内接种后在叙利亚仓鼠中表现出减弱的表型。其特征是病毒复制减少以及下呼吸道的肺部病变减轻。在此，我们报告，经气管接种奥密克戎BA.1可恢复下呼吸道的复制和致病性，这与其他谱系所观察到的情况相同。
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