Sardanyés Josep, Perales Celia, Domingo Esteban, Elena Santiago F
Centre de Recerca Matemàtica (CRM), Edifici C, Campus de Bellaterra, Cerdanyola del Vallès, Barcelona, Spain.
Dynamical Systems and Computational Virology, CSIC Associated Unit I2SysBio-CRM, Cerdanyola del Vallès, Barcelona, Spain.
Npj Viruses. 2024 Nov 14;2(1):54. doi: 10.1038/s44298-024-00066-w.
Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory's role in virus-host interactions, including immune evasion, drug resistance, and viral emergence. We review the original model, recent advances, and key virus dynamics needing incorporation into quasispecies theory. We introduce the ultracube concept as a more realistic multidimensional sequence space to investigate virus evolutionary dynamics.
准种理论彻底改变了我们对病毒进化的理解，它将病毒描述为不断适应的具有遗传多样性变体的动态群体。本文探讨了该理论在病毒与宿主相互作用中的作用，包括免疫逃逸、耐药性和病毒出现。我们回顾了原始模型、最新进展以及需要纳入准种理论的关键病毒动态。我们引入超立方体概念作为一个更现实的多维序列空间来研究病毒进化动态。
