Santhakumar S, Deshmukh Karan, Mehta Sangita Sharma, Muthusamy Rajeshwari K, Venugopal J, Deepak T H, Karthi N, Sharmila S, Joseph Ananthu, Kurdula Thanushree
Department of Pulmonology, KMCH, Coimbatore, Tamil Nadu, India.
Department of Pathology, KMCH, Coimbatore, Tamil Nadu, India.
Lung India. 2025 May 1;42(3):252-255. doi: 10.4103/lungindia.lungindia_531_23. Epub 2025 Apr 29.
Endobronchial ultrasound (EBUS) guided mediastinal cryobiopsy is a novel technique which can be combined with EBUS -TBNA to improve the diagnostic yield. Recent studies report, this technique is safe and superior to EBUS TBNA alone in terms of acquisition of larger tissue samples and thereby a better diagnostic yield and adequacy of tissue for molecular studies. However, safety of this technique in patients do not tolerate a bronchoscopic procedure due to hypoxia or respiratory distress is not clarified yet. Alternatively, EBUS guided FNA via trans-esophageal route(EUS-B-FNA) is a proven technique with a similar diagnostic yield as EBUS TBNA with a better tolerance and a more patient comfort. We report two patients here, in whom EUS- B guided cryobiopsy was successfully done via trans-esophageal route, due to intolerance for bronchoscopic procedure and inconclusive ROSE reports.
支气管内超声（EBUS）引导下纵隔冷冻活检是一种新技术，可与EBUS-TBNA联合使用以提高诊断率。近期研究报道，该技术安全，在获取更大组织样本方面优于单纯的EBUS-TBNA，从而具有更高的诊断率以及更适合分子研究的组织样本量。然而，对于因缺氧或呼吸窘迫而无法耐受支气管镜检查的患者，该技术的安全性尚不清楚。另外，经食管途径的EBUS引导下细针穿刺抽吸活检术（EUS-B-FNA）是一种成熟的技术，其诊断率与EBUS-TBNA相似，耐受性更好，患者舒适度更高。我们在此报告两例患者，由于无法耐受支气管镜检查且快速现场评价（ROSE）报告结果不明确，经食管途径成功完成了EUS-B引导下冷冻活检。
