Manolov Nayden H, Postadzhiyan Arman Sh, Karabeliova Sonya M, Marinov Peter M
Department of General Medicine, Medical University Sofia, Bulgaria.
Department of Psychology, Sofia University 'St. KlimentOhridski', Bulgaria.
Compr Psychoneuroendocrinol. 2025 Apr 10;22:100292. doi: 10.1016/j.cpnec.2025.100292. eCollection 2025 May.
Assessment of diabetic peripheral neuropathy (DPN) usually focuses on nerve damage resulting from hyperglycaemia. However, screening for common psychiatric disorders may improve the recognition of psychopathology in patients with DPN. This epidemiological cohort study aimed to evaluate the prevalence of panic attack symptoms in patients with DPN compared toa control group of healthy individuals without type 2 diabetes mellitusorDPN.Additionally, this study sought to compare the severity of these symptoms between the two groups.The study was conducted via a survey over three years in an accredited practice of physicians at the Medical University-Sofia. A total of267 participants were included, comprising 83 patients with DPN and 184healthy controls. Both groups completed the Prime-MD Patient Health Questionnaire. The results indicated significant differences between the two study groups([127.513] = 3.293; < 0.01), and patients with DPN had a higher prevalence of panic attack symptoms than those in the control group.Furthermore, significant differences were observed in the severity of panic attack symptoms within the DPN group ([(81] = 2.017, < 0.05).Patients who had experienced DPN for more than one year reported more severe symptoms than those who had experienced it for less than oneyear. Our results indicate that the high prevalence of panic attack symptoms inpatients with DPN highlights the need for integrated screening for psychiatric disorders within the overall management plan for diabetes mellitus.
糖尿病周围神经病变(DPN)的评估通常聚焦于高血糖导致的神经损伤。然而,筛查常见精神障碍可能会提高对DPN患者精神病理学的识别。这项流行病学队列研究旨在评估DPN患者与无2型糖尿病或DPN的健康个体对照组相比惊恐发作症状的患病率。此外,本研究试图比较两组之间这些症状的严重程度。该研究通过在索菲亚医科大学一家经认可的医生诊所进行的为期三年的调查开展。总共纳入了267名参与者,包括83名DPN患者和184名健康对照。两组均完成了简明国际神经精神访谈(Prime-MD)患者健康问卷。结果表明两个研究组之间存在显著差异([127.513] = 3.293;<0.01),DPN患者惊恐发作症状的患病率高于对照组。此外,在DPN组内惊恐发作症状的严重程度也观察到显著差异([(81] = 2.017,<0.05)。DPN病程超过一年的患者报告的症状比病程少于一年的患者更严重。我们的结果表明,DPN患者中惊恐发作症状的高患病率凸显了在糖尿病总体管理计划中对精神障碍进行综合筛查的必要性。