Du Weibin, Zhai Xiaojun, Li Yong
Research Institute of Orthopedics, The Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, 156 Yucai Road, Xiaoshan District, Hangzhou City, Zhejiang Province 311201, China.
Department of Orthopaedics, Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, 156 Yucai Road, Xiaoshan District, Hangzhou City, Zhejiang Province 311201, China.
J Surg Case Rep. 2025 Apr 28;2025(4):rjaf245. doi: 10.1093/jscr/rjaf245. eCollection 2025 Apr.
To investigate the efficacy of tranexamic acid combined with desmopressin in reducing intraoperative and postoperative bleeding during severe spinal deformity correction surgery. Around 30 cases of orthopedic surgery for severe spinal deformity were included in this study. They were divided into study group and control group. The surgical duration, intraoperative blood loss, postoperative 24-h drainage volume, hemoglobin levels, and coagulation function indicators at 24 h postoperatively were recorded and compared between the two groups. The intraoperative blood loss and 24-h postoperative drainage volume of the study group were significantly lower than those of the control group ( < 0.05). The decrease in hemoglobin levels was less pronounced in the study group, and the coagulation function indicators remained more stable within 24 h postoperatively. Compared with the control group, both < 0.05. The combination of tranexamic acid and desmopressin effectively reduces intraoperative and postoperative bleeding in severe spinal deformity correction surgery, and demonstrates a favorable safety profile.
探讨氨甲环酸联合去氨加压素在重度脊柱畸形矫正手术中减少术中及术后出血的疗效。本研究纳入约30例重度脊柱畸形矫形手术患者。将其分为研究组和对照组。记录并比较两组的手术时长、术中失血量、术后24小时引流量、血红蛋白水平及术后24小时的凝血功能指标。研究组的术中失血量和术后24小时引流量显著低于对照组（<0.05）。研究组血红蛋白水平下降不明显，术后24小时内凝血功能指标保持更稳定。与对照组相比，均<0.05。氨甲环酸与去氨加压素联合应用可有效减少重度脊柱畸形矫正手术中的术中及术后出血，并显示出良好的安全性。
