Zhou Xue, Guo Ting, Lin Liangfeng
Department of Pediatrics, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Noise Health. 2025;27(125):128-134. doi: 10.4103/nah.nah_181_24. Epub 2025 Apr 29.
Objective To investigate the effects of occupational noise exposure on disease control and psychological status in patients with diabetic nephropathy.
A cross-sectional study was conducted on 306 patients with diabetic nephropathy who visited the Second Affiliated Hospital of Fujian Medical University between January 2022 and January 2024. The patients were divided into two groups based on their occupational noise exposure level as follows: Group A (noise level ≥55 dB, 148 cases) and Group B (noise level <55 dB, 158 cases). The general information, noise exposure levels, glycaemic indicators [glycosylated haemoglobin (HbA1c), fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG), glycated serum protein (GSP)], renal function indicators [blood urea nitrogen (BUN), urinary albumin excretion rate (UAER), serum creatinine (SCr), 24-hour urinary protein (24hUP)] and psychological status [Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS)] were compared between Groups A and B. Univariate analysis was performed using Pearson correlation analysis.
No significant differences were observed in age, gender and body mass index between the two groups (P > 0.05). However, glycaemic indicators such as HbA1c, FPG, PBG, GSP; renal function indicators such as BUN, UAER, SCr, 24hUP and psychological status (SAS and SDS scores) in Group A were significantly higher than those in Group B (P < 0.05). A significantly positive association was found between noise levels with SDS score (r = 0.321), FPG (r = 0.320) and UAER level (r = 0.405) (P < 0.001).
This study reveals that occupational noise exposure negatively impacts disease control and psychological status in patients with diabetic nephropathy. Therefore, focusing on noise control in clinical practice is essential.
目的 探讨职业噪声暴露对糖尿病肾病患者疾病控制及心理状态的影响。
对2022年1月至2024年1月期间就诊于福建医科大学附属第二医院的306例糖尿病肾病患者进行横断面研究。根据职业噪声暴露水平将患者分为两组：A组（噪声水平≥55分贝，148例）和B组（噪声水平<55分贝，158例）。比较A、B两组的一般资料、噪声暴露水平、血糖指标[糖化血红蛋白（HbA1c）、空腹血糖（FPG）、餐后2小时血糖（2hPG）、糖化血清蛋白（GSP）]、肾功能指标[血尿素氮（BUN）、尿白蛋白排泄率（UAER）、血清肌酐（SCr）、24小时尿蛋白（24hUP）]及心理状态[焦虑自评量表（SAS）和抑郁自评量表（SDS）]。采用Pearson相关分析进行单因素分析。
两组患者在年龄﹑性别及体重指数方面差异无统计学意义（P>0.05）。然而，A组的血糖指标如HbA1c、FPG、餐后血糖、GSP；肾功能指标如BUN、UAER、SCr、24hUP及心理状态（SAS和SDS评分）均显著高于B组（P<0.05）。发现噪声水平与SDS评分（r=0.321）、FPG（r=0.320）及UAER水平（r=0.405）之间存在显著正相关（P<0.001）。
本研究表明职业噪声暴露对糖尿病肾病患者的疾病控制及心理状态有负面影响。因此，在临床实践中关注噪声控制至关重要。
