Zhang Shujian, Shen Li, Wang Qian, Yu Shuhong
Department of Nephrology, Qingdao Municipal Hospital, Qingdao, China.
Department of Neurology, Qingdao Municipal Hospital, Qingdao, China.
Noise Health. 2024;26(123):559-565. doi: 10.4103/nah.nah_106_24. Epub 2024 Dec 30.
This study aimed to explore the relationship between occupational noise exposure and renal dysfunction in male workers.
A total of 160 male workers (the number of people who met the inclusion criteria) who underwent health examinations in Qingdao Municipal Hospital from January 2023 to December 2023 were grouped into a noise group (80 cases) and a control group (80 cases) based on whether they engaged in noise work. We compared the differences in creatinine (CREA), cystatin C (CysC) and blood urea nitrogen (BUN) levels between the two groups. We also compared the differences in the above renal function indicators among workers with different working years in the noise group, as well as observed the relationship between renal dysfunction and noise exposure.
The levels of BUN, CREA and CysC in the noise group were significantly higher than those in the control group (P < 0.05). The overall abnormal rate of renal function in the noise group (42.50%) was significantly higher than that in the control group (11.25%, P < 0.05). The levels of BUN, CREA and CysC all significantly increased with the increase in working years (P < 0.05). The noise exposure intensity and cumulative noise exposure (CNE) of the group with renal dysfunction were higher than those of the group with normal renal function (P < 0.05). The area under the curve was 0.811 (95% confidence interval: 0.714-0.908), the optimal cut-off value of CNE was 96.53 dB (A) · year, the sensitivity was 89.29%, the specificity was 83.32% and the Youden index was 72.61%.
There may be a correlation between long-term noise exposure and renal function. The intensity of noise exposure and CNE may have a certain correlation with renal function damage in occupational noise-exposed workers.
本研究旨在探讨男性工人职业噪声暴露与肾功能障碍之间的关系。
选取2023年1月至2023年12月在青岛市立医院进行健康体检的160名男性工人（符合纳入标准的人数），根据是否从事噪声工作分为噪声组（80例）和对照组（80例）。比较两组肌酐（CREA）、胱抑素C（CysC）和血尿素氮（BUN）水平的差异。同时比较噪声组中不同工龄工人上述肾功能指标的差异，并观察肾功能障碍与噪声暴露之间的关系。
噪声组的BUN、CREA和CysC水平显著高于对照组（P<0.05）。噪声组肾功能总体异常率（42.50%）显著高于对照组（11.25%，P<0.05）。BUN、CREA和CysC水平均随工龄增加而显著升高（P<0.05）。肾功能障碍组的噪声暴露强度和累积噪声暴露（CNE）高于肾功能正常组（P<0.05）。曲线下面积为0.811（95%置信区间：0.714 - 0.908），CNE的最佳截断值为96.53 dB（A）·年，灵敏度为89.29%，特异度为83.32%，约登指数为72.61%。
长期噪声暴露与肾功能可能存在相关性。噪声暴露强度和CNE可能与职业噪声暴露工人的肾功能损害存在一定相关性。
