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老年型枢椎Ⅱ型骨折:新型接骨板与普通前路螺钉固定相比的生物力学优势

Geriatric Type II Fractures of the Dens Axis: Biomechanical Superiority of a New Osteosynthesis Plate Compared to Common Anterior Screw Fixation.

作者信息

Leonhardt Leon-Gordian, Münch Matthias, Schroeder Malte, Dirks Michael, Kleinertz Holger, Kammal Anna Lena, Ondruschka Benjamin, von Kroge Simon, Rolvien Tim, Frosch Karl-Heinz, Bay Annika, Viezens Lennart

机构信息

Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Laboratory for Biomechanics, BG Klinikum Hamburg, Germany.

出版信息

Global Spine J. 2025 Apr 29:21925682251338814. doi: 10.1177/21925682251338814.

DOI:10.1177/21925682251338814
PMID:40298318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040855/
Abstract

Study DesignBiomechanical Basic Research.ObjectivesType II Fractures of the dens axis (DFTII) are common fractures of the cervical spine in geriatric patients. A surgical approach is the anterior screw fixation (ASF). However, a disadvantage is the high post-operative rate of non-union. This study aimed to develop and biomechanically test an osteosynthesis plate (OSP) for the anterior treatment of DFTII in comparison to ASF.MethodsA novel OSP was developed and manufactured. The OSP was biomechanically tested in comparison to ASF in synthetic bone models and geriatric human cadaveric bone. An analysis of the bone microstructure of the human C2 vertebrae was performed utilizing high-resolution quantitative computed tomography to exclude differences in bone quality among the experimental groups. Biomechanical testing was performed by cyclic loading of compression and tensile forces until failure.ResultsIn the comparative biomechanical analysis of ASF and OSP in synthetic bone, significant differences were observed regarding the load to failure, favoring the OSP ( = 0.040). The comparative biomechanical analysis of ASF and OSP in the cadaveric specimens also revealed a significantly lower load to failure of the ASF ( = 0.046). The experimental groups did not show significant differences regarding age, sex or bone microstructure.ConclusionsThe current study demonstrated that the OSP is biomechanically superior to the ASF, indicating higher stability. This study provides the basis for an alternative anterior treatment option for DFTII.

摘要

研究设计

生物力学基础研究。

目的

齿状突Ⅱ型骨折(DFTII)是老年患者常见的颈椎骨折。手术方法是前路螺钉固定(ASF)。然而,其缺点是术后不愈合率高。本研究旨在开发一种用于DFTII前路治疗的接骨板(OSP)并进行生物力学测试,与ASF进行比较。

方法

开发并制造了一种新型OSP。在合成骨模型和老年人体尸体骨中,将OSP与ASF进行生物力学测试。利用高分辨率定量计算机断层扫描对人C2椎体的骨微结构进行分析,以排除实验组之间骨质量的差异。通过施加压缩和拉伸力的循环加载直至失效来进行生物力学测试。

结果

在合成骨中对ASF和OSP进行的比较生物力学分析中,在失效载荷方面观察到显著差异,OSP更具优势(P = 0.040)。在尸体标本中对ASF和OSP进行的比较生物力学分析也显示,ASF的失效载荷显著更低(P = 0.046)。实验组在年龄、性别或骨微结构方面未显示出显著差异。

结论

当前研究表明,OSP在生物力学上优于ASF,表明其稳定性更高。本研究为DFTII的另一种前路治疗选择提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/4e27c6ec2798/10.1177_21925682251338814-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/e1d13814fc95/10.1177_21925682251338814-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/5af2c19f1f9b/10.1177_21925682251338814-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/110e3ce55695/10.1177_21925682251338814-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/f506ec7aa059/10.1177_21925682251338814-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/59d7aa8aa8a6/10.1177_21925682251338814-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/4e27c6ec2798/10.1177_21925682251338814-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/e1d13814fc95/10.1177_21925682251338814-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/5af2c19f1f9b/10.1177_21925682251338814-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/110e3ce55695/10.1177_21925682251338814-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/f506ec7aa059/10.1177_21925682251338814-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/59d7aa8aa8a6/10.1177_21925682251338814-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccd4/12040855/4e27c6ec2798/10.1177_21925682251338814-fig6.jpg

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本文引用的文献

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2
Geriatric Odontoid Fractures: Treatment Algorithms of the German Society for Orthopaedics and Trauma Based on Expert Consensus and a Systematic Review.老年齿状突骨折:基于专家共识和系统评价的德国骨科与创伤学会治疗算法
Global Spine J. 2023 Apr;13(1_suppl):13S-21S. doi: 10.1177/21925682231157316.
3
Analysis of Three-Dimensional Bone Microarchitecture of the Axis Exposes Pronounced Regional Heterogeneity Associated with Clinical Fracture Patterns.
分析寰枢椎的三维骨微结构揭示了与临床骨折模式相关的显著区域性异质性。
Calcif Tissue Int. 2023 May;112(5):563-572. doi: 10.1007/s00223-023-01070-7. Epub 2023 Feb 24.
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The limitations of fully threaded screws in isolated percutaneous transarticular screw fixation of C1/C2.全螺纹螺钉在 C1/C2 经皮关节突螺钉固定中的局限性。
Sci Rep. 2022 Apr 20;12(1):6484. doi: 10.1038/s41598-022-10447-x.
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A biomechanical comparison of a cement-augmented odontoid screw with a posterior-instrumented fusion in geriatric patients with an odontoid fracture type IIb.老年Ⅱb 型齿状突骨折患者骨水泥增强型齿突螺钉与后路内固定融合的生物力学比较。
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